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PMID: 225301 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Extrachromosomal psi+ determinant suppresses nonsense mutations in yeast.

Journal of bacteriology ·Vol. 139 ·No. 3 ·1979-09-00 ·Pages 1068-71

Liebman SW, Sherman F

Abstract

The extrachromosomal psi+ determinant in the yeast Saccharomyces cerevisiae enhanced the expression of Mendelian UAA suppressors by 6- to 10-fold. The psi+ determinant by itself is a weak UAA suppressor that caused the production of approximately 1% of the normal level of iso-1-cytochrome c in a strain containing the UAA mutation cycl-72.

MeSH Terms
Cytochrome c Group/analysis Extrachromosomal Inheritance Mutation Saccharomyces cerevisiae/genetics Species Specificity Spectrophotometry Suppression, Genetic
Chemicals
Cytochrome c Group
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Liebman S W
Sherman F
References (7)
7 references, click to expand
  1. Genetics and biosynthesis of cytochrome c.
    Annu Rev Genet. 1971;5:257-96 PMID: 16097658
  2. Frameshifts and frameshift suppressors in Saccharomyces cerevisiae.
    Genetics. 1977 Aug;86(4):745-64 PMID: 72702
  3. Structural gene for yeast iso-2-cytochrome c.
    J Mol Biol. 1977 Jun 25;113(2):369-84 PMID: 196092
  4. Extrachromosomal elements in a super-suppression system of yeast. II. Relations with other extrachromosomal elements.
    Heredity (Edinb). 1972 Apr;28(2):189-99 PMID: 4555664
  5. Demonstration of UAG as a nonsense codon in bakers' yeast by amino-acid replacements in iso-1-cytochrome c.
    J Mol Biol. 1972 Jul 28;68(3):429-43 PMID: 4560848
  6. Identification and mutational relocation of the AUG codon initiating translation of iso-1-cytochrome c in yeast.
    J Biol Chem. 1971 Dec 25;246(24):7429-45 PMID: 5135310
  7. Genetic determination of iso-cytochromes c in yeast.
    J Mol Biol. 1965 Aug;13(1):21-39 PMID: 5859036
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.139.3.1068-1071.1979
Published
1979-09-00
Pages
1068-71
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC218059
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.139.3.1068-1071.1979 PMC Full Text View journal details
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