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PMID: 225524 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Simian virus 40 t antigen affects the sensitivity of cellular DNA synthesis to theophylline.

Journal of virology ·Vol. 30 ·No. 1 ·1979-04-00 ·Pages 394-6

Rundell K, Cox J

Abstract

Cellular DNA synthesis induced by simian virus 40 mutants that lack t antigen is sensitive to concentrations of theophylline that do not affect wild-type-induced synthesis.

MeSH Terms

Animals Antigens, Viral/genetics Cell Line DNA/biosynthesis Haplorhini Kidney Mutation Simian virus 40/genetics,immunology Theophylline/pharmacology Thymidine Kinase/biosynthesis

Chemicals

Antigens, Viral DNA Theophylline Thymidine Kinase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rundell K

Cox J

References (9)

9 references, click to expand

Cellular alterations dependent upon the polyoma virus Hr-t function: separation of mitogenic from transforming capacities.
Cell. 1978 Jul;14(3):587-99 PMID: 210955
New region of the simian virus 40 genome required for efficient viral transformation.
Proc Natl Acad Sci U S A. 1978 May;75(5):2473-7 PMID: 209467
Organization and expression of early genes of simian virus 40.
Proc Natl Acad Sci U S A. 1978 Jan;75(1):117-21 PMID: 203926
Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells.
Cell. 1978 May;14(1):79-88 PMID: 208777
Inhibition of cell growth in the G1 phase by adenosine 3', 5'-cyclic monophosphate.
J Cell Biol. 1974 Jan;60(1):249-57 PMID: 4358429
Selective extraction of polyoma DNA from infected mouse cell cultures.
J Mol Biol. 1967 Jun 14;26(2):365-9 PMID: 4291934
The requirement of simian virus 40 gene A product for the stimulation of cellular thymidine kinase activity after viral infection.
Virology. 1976 Aug;73(1):206-15 PMID: 183353
Construction and analysis of viable deletion mutants of simian virus 40.
J Virol. 1976 May;18(2):664-71 PMID: 178902
Altered patterns of protein synthesis in infection by SV40 mutants.
Cold Spring Harb Symp Quant Biol. 1975;39 Pt 1:9-15 PMID: 169100

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.30.1.394-396.1979

Published

1979-04-00

Pages

394-6

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC353334

Subset

External Links

PubMed source DOI: 10.1128/JVI.30.1.394-396.1979 PMC Full Text View journal details

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Simian virus 40 t antigen affects the sensitivity of cellular DNA synthesis to theophylline.

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