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PMID: 225525 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Neoplastic transformation of cultured Syrian hamster embryo cells by DNA of herpes simplex virus type 2.

Journal of virology ·Vol. 30 ·No. 1 ·1979-04-00 ·Pages 404-9

Jariwalla RJ, Aurelian L, Ts'o PO

Abstract

Syrian hamster embryo cells were transformed to a neoplastic phenotype after exposure to herpes simplex virus type 2 (S-1) DNA at concentrations (less than or equal to 0.01 microgram per 60-mm dish) at which infectivity was no longer demonstrable. Transformed cells manifested in vitro phenotypic properties characteristic of the neoplastic state, expressed herpes simplex virus-specific antigens, and induced invasive tumors in vivo. Transfection and transformation of Syrian hamster embryo cells with herpes simplex virus type 2 DNA or its fragments is a suitable system for investigating the structure and function of herpes simplex virus-transforming gene(s).

MeSH Terms
Animals Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Clone Cells Cricetinae DNA, Viral Mesocricetus Neoplasm Transplantation Phenotype Simplexvirus/genetics Transfection
Chemicals
DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jariwalla R J
Aurelian L
Ts'o P O
References (25)
25 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.30.1.404-409.1979
Published
1979-04-00
Pages
404-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC353337
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.30.1.404-409.1979 PMC Full Text View journal details
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