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PMID: 2256889 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mixed-model segregation analysis of schizophrenia in the Lindelius Swedish pedigrees.

Behavior genetics ·Vol. 20 ·No. 4 ·1990-07-00 ·Pages 461-72

Vogler GP, Gottesman II, McGue MK, Rao DC

Abstract

To test if familial transmission of schizophrenia is consistent with a model of monogenic inheritance with a multifactorial background, a mixed-model segregation analysis was applied to Swedish pedigrees consisting of 270 probands in 263 nuclear families. Results of the best-fitting mixed-model solutions are consistent with multifactorial transmission and no major gene. However, numerical instabilities prevented formal hypothesis testing, so an irrefutable genetic mechanism remains unidentified. Alternative research strategies that exploit recent advances in molecular genetics are discussed.

MeSH Terms
Female Humans Male Models, Genetic Pedigree Risk Factors Schizophrenia/genetics Sweden
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Vogler G P
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110.
Gottesman I I
McGue M K
Rao D C
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Article Info
Journal
Behavior genetics
Abbr.
Behav Genet
ISSN
0001-8244
DOI
10.1007/BF01067712
Published
1990-07-00
Pages
461-72
Language
English
Region
United States
NLM ID
0251711
Subset
IM
Grants
NIGMS NIH HHS · GM 28719 · United States
NIMH NIH HHS · MH 17104 · United States
External Links
PubMed source DOI: 10.1007/BF01067712 View journal details
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