Calmodulin activation of adenylate cyclase in pancreatic islets.

Science (New York, N.Y.) ·Vol. 206 ·No. 4415 ·1979-10-12 ·Pages 225-7

Valverde I, Vandermeers A, Anjaneyulu R, Malaisse WJ

Abstract

Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.

MeSH Terms

Adenylyl Cyclases/metabolism Animals Calcium/physiology Calcium-Binding Proteins/metabolism Calmodulin/metabolism Cell Membrane/metabolism Cyclic AMP/metabolism Egtazic Acid/metabolism Enzyme Activation Female Glucose/pharmacology Insulin/metabolism Insulin Secretion Islets of Langerhans/enzymology Kinetics Rats

Chemicals

Calcium-Binding Proteins Calmodulin Insulin Egtazic Acid Cyclic AMP Adenylyl Cyclases Glucose Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Valverde I

Vandermeers A

Anjaneyulu R

Malaisse W J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.225798

Published

1979-10-12

Pages

225-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.225798 View journal details

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