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PMID: 22615594 Published · ppublish English Journal Article

Effects of aminoguanidine on infertile varicocelized rats: A functional and morphological study.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences ·Vol. 18 ·No. 1 ·2010-00-00 ·Pages 51-6

Alizadeh N, Abbasi M, Abolhassani F, Amidi F, Mahmoudi R, Hoshino Y, Sato E, Ragerdikashani I

Abstract

BACKGROUNDS AND THE PURPOSE OF THE STUDY: Inducible NO synthase activity has been frequently reported in varicose veins. Aminoguanidine is known to inhibit iNOS. The aim of this study was to examine the effects of aminoguanidine on varicocelized rats. Male Wistar rats were divided into groups A, B, C, D, E, and F (control group). Groups A, B, C, and D rats underwent left varicocele induction with a 20-gauge needle. Group E (sham) rats underwent a similar procedure, but the renal vein was left intact. Ten weeks after varicocele induction, sperm parameters were evaluated in groups D, E, and F. Groups A and B received 50 mg/kg aminoguanidine or placebo, respectively, daily for 10 weeks. After 10 and 20 weeks of varicocele induction, the fertility outcomes of the experimental groups were evaluated. The values of the sperm parameters did not differ significantly between groups B and D, but were significant when compared with groups F and E (P≤0.05). The values of the sperm parameters of groups F and E showed no significant changes (P≤0.05). The changes between group A and groups B and D were significant (P≤0.05). Ten weeks after varicocele induction, rats of groups A, B, and C were still fertile. After 20 weeks, only half of the rats in group A were fertile. Aminoguanidine improved the sperm parameters and mating outcomes in vari-cocelized rats.

Keywords
Aminoguanidine Fertility Sperm Varicocele
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Alizadeh N
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences.
Abbasi M
Abolhassani F
Amidi F
Mahmoudi R
Hoshino Y
Sato E
Ragerdikashani I
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Article Info
Journal
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Abbr.
Daru
ISSN
1560-8115
Published
2010-00-00
Pages
51-6
Language
English
Region
Switzerland
NLM ID
101125969
PMCID
PMC3232080
External Links
PubMed source PMC Full Text
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