Hyperinsulinaemia increases insulin action in vivo in white adipose tissue but not in muscles.
The effect of 4 days of stable hyperglycaemia and resulting hyperinsulinaemia on insulin-induced glucose utilization by individual rat tissues was studied in vivo. The treatment produced a net increase in the glucose utilization index under both basal and insulin-stimulated (euglycaemic/hyperinsulinaemic clamp) conditions in white adipose tissue. On the contrary, glucose utilization was unchanged in aerobic muscles but was decreased in glycolytic skeletal muscles during the clamp.
15 references, click to expand
-
Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites.Biochem J. 1980 Feb 15;186(2):525-34 PMID: 6990920
-
Metabolic consequences of hyperinsulinaemia imposed on normal rats on glucose handling by white adipose tissue, muscles and liver.Biochem J. 1990 Apr 1;267(1):99-103 PMID: 2183797
-
Increased insulin responsiveness in vivo and in vitro consequent to induced hyperinsulinemia in the rat.Diabetes. 1984 May;33(5):444-9 PMID: 6144606
-
Inter- and intraspecies comparisons of fibre type distribution and of succinate dehydrogenase activity in type I, IIA and IIB fibres of mammalian diaphragms.Histochemistry. 1984;81(1):67-73 PMID: 6469723
-
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat.Biochem J. 1985 May 15;228(1):103-10 PMID: 3890836
-
Regulation of glucose utilization in adipose cells and muscle after long-term experimental hyperinsulinemia in rats.J Clin Invest. 1985 Aug;76(2):460-9 PMID: 3897286
-
Increased muscle glucose uptake after exercise. No need for insulin during exercise.Diabetes. 1985 Oct;34(10):1041-8 PMID: 3899806
-
In vivo metabolic changes as studied longitudinally after ventromedial hypothalamic lesions.Am J Physiol. 1986 Jun;250(6 Pt 1):E662-8 PMID: 3521313
-
Neuro-endocrine disorders seen as triggers of the triad: obesity--insulin resistance--abnormal glucose tolerance.Diabetes Metab Rev. 1985;1(3):261-91 PMID: 3915255
-
Activation of glucose transport in muscle by prolonged exposure to insulin. Effects of glucose and insulin concentrations.J Biol Chem. 1986 Dec 5;261(34):16049-53 PMID: 3536920
-
Insulin insensitivity and skeletal muscle enzyme activities in response to overinsulinization in the rat.Metabolism. 1987 Mar;36(3):281-5 PMID: 3102896
-
Development of obesity in Zucker rats. Early insulin resistance in muscles but normal sensitivity in white adipose tissue.Diabetes. 1987 May;36(5):626-31 PMID: 3552794
-
In vivo insulin secretion and action in hyperglycemic rat.Am J Physiol. 1989 Aug;257(2 Pt 1):E180-4 PMID: 2669513
-
Development of VMH obesity: in vivo insulin secretion and tissue insulin sensitivity.Am J Physiol. 1989 Aug;257(2 Pt 1):E255-60 PMID: 2669518
-
Hyperglycaemia induced by glucose infusion in the unrestrained pregnant rat during the last three days of gestation: metabolic and hormonal changes in the mother and the fetuses.Diabetologia. 1981 Dec;21(6):569-74 PMID: 7040146
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
