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PMID: 22655178 Published · ppublish English Journal Article

Fetal programming of body composition, obesity, and metabolic function: the role of intrauterine stress and stress biology.

Journal of nutrition and metabolism ·Vol. 2012 ·2012-00-00 ·Pages 632548

Entringer S, Buss C, Swanson JM, Cooper DM, Wing DA, Waffarn F, Wadhwa PD

Abstract

Epidemiological, clinical, physiological, cellular, and molecular evidence suggests that the origins of obesity and metabolic dysfunction can be traced back to intrauterine life and supports an important role for maternal nutrition prior to and during gestation in fetal programming. The elucidation of underlying mechanisms is an area of interest and intense investigation. In this perspectives paper we propose that in addition to maternal nutrition-related processes it may be important to concurrently consider the potential role of intrauterine stress and stress biology. We frame our arguments in the larger context of an evolutionary-developmental perspective that supports roles for both nutrition and stress as key environmental conditions driving natural selection and developmental plasticity. We suggest that intrauterine stress exposure may interact with the nutritional milieu, and that stress biology may represent an underlying mechanism mediating the effects of diverse intrauterine perturbations, including but not limited to maternal nutritional insults (undernutrition and overnutrition), on brain and peripheral targets of programming of body composition, energy balance homeostasis, and metabolic function. We discuss putative maternal-placental-fetal endocrine and immune/inflammatory candidate mechanisms that may underlie the long-term effects of intrauterine stress. We conclude with a commentary of the implications for future research and clinical practice.

Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Entringer Sonja
Department of Pediatrics, School of Medicine, University of California, Irvine, CA 92697-4260, USA.
Buss Claudia
Swanson James M
Cooper Dan M
Wing Deborah A
Waffarn Feizal
Wadhwa Pathik D
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Article Info
Journal
Journal of nutrition and metabolism
Abbr.
J Nutr Metab
ISSN
2090-0732
DOI
10.1155/2012/632548
Published
2012-00-00
Epub
2012-00-10
Pages
632548
Language
English
Region
United States
NLM ID
101526296
PMCID
PMC3359710
Grants
NICHD NIH HHS · P01 HD047609 · United States
NICHD NIH HHS · R01 HD060628 · United States
NICHD NIH HHS · R01 HD065825 · United States
External Links
PubMed source DOI: 10.1155/2012/632548 PMC Full Text View journal details
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