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PMID: 22675355 Published · ppublish English Journal Article

Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions.

International journal of endocrinology ·Vol. 2012 ·2012-00-00 ·Pages 983814

Snel M, Jonker JT, Schoones J, Lamb H, de Roos A, Pijl H, Smit JW, Meinders AE, Jazet IM

Abstract

The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, skeletal muscle, and heart seem to disrupt metabolic processes and impair organ function. We describe the mechanisms of ectopic fat depositions in the liver, skeletal muscle, and in and around the heart and the consequences for each organs function. In addition, we systematically reviewed the literature for the effects of diet-induced weight loss and exercise on ectopic fat depositions.

Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Snel M
Departments of Endocrinology & Metabolism and General Internal Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Jonker J T
Schoones J
Lamb H
de Roos A
Pijl H
Smit J W A
Meinders A E
Jazet I M
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Article Info
Journal
International journal of endocrinology
Abbr.
Int J Endocrinol
ISSN
1687-8345
DOI
10.1155/2012/983814
Published
2012-00-00
Epub
2012-00-24
Pages
983814
Language
English
Region
Egypt
NLM ID
101516376
PMCID
PMC3366269
External Links
PubMed source DOI: 10.1155/2012/983814 PMC Full Text View journal details
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