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PMID: 22722082 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Role of epoxide hydrolases in lipid metabolism.

Biochimie ·Vol. 95 ·No. 1 ·2013-01-00 ·Pages 91-5

Morisseau C

Abstract

Epoxide hydrolases (EH), enzymes present in all living organisms, transform epoxide-containing lipids to 1,2-diols by the addition of a molecule of water. Many of these oxygenated lipid substrates have potent biological activities: host defense, control of development, regulation of blood pressure, inflammation, and pain. In general, the bioactivity of these natural epoxides is significantly reduced upon metabolism to diols. Thus, through the regulation of the titer of lipid epoxides, EHs have important and diverse biological roles with profound effects on the physiological state of the host organism. This review will discuss the biological activity of key lipid epoxides in mammals. In addition, the use of EH specific inhibitors will be highlighted as possible therapeutic disease interventions.

MeSH Terms
Animals Cholesterol/analogs & derivatives,chemistry,genetics,metabolism Epoxide Hydrolases/chemistry,genetics,metabolism Epoxy Compounds/chemistry,metabolism Juvenile Hormones/biosynthesis,genetics,metabolism Lipid Metabolism/genetics,physiology Mammals Microsomes/enzymology,metabolism Solubility
Chemicals
Epoxy Compounds Juvenile Hormones cholesterol alpha-oxide Cholesterol Epoxide Hydrolases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Morisseau Christophe
Department of Entomology and U.C.D. Comprehensive Cancer Center, One Shields Avenue, University of California, Davis, CA 95616, USA. [email protected]
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Article Info
Journal
Biochimie
Abbr.
Biochimie
ISSN
1638-6183
DOI
10.1016/j.biochi.2012.06.011
Email
[email protected]
Published
2013-01-00
Epub
2012-00-18
Pages
91-5
Language
English
Region
France
NLM ID
1264604
PMCID
PMC3495083
Subset
IM
Grants
NIEHS NIH HHS · P42 ES004699 · United States
NIEHS NIH HHS · R01 ES002710 · United States
NIEHS NIH HHS · P42 ES04699 · United States
External Links
PubMed source DOI: 10.1016/j.biochi.2012.06.011 PMC Full Text View journal details
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