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PMID: 22772564 Published · epublish English Journal Article Research Support, N.I.H., Intramural Review

Mechanisms of fibrosis: therapeutic translation for fibrotic disease.

Nature medicine ·Vol. 18 ·No. 7 ·2012-07-06 ·Pages 1028-40

Wynn TA, Ramalingam TR

Abstract

Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or scarring, is defined by the accumulation of excess extracellular matrix components. If highly progressive, the fibrotic process eventually leads to organ malfunction and death. Fibrosis affects nearly every tissue in the body. Here we discuss how key components of the innate and adaptive immune response contribute to the pathogenesis of fibrosis. We also describe how cell-intrinsic changes in important structural cells can perpetuate the fibrotic response by regulating the differentiation, recruitment, proliferation and activation of extracellular matrix-producing myofibroblasts. Finally, we highlight some of the key mechanisms and pathways of fibrosis that are being targeted as potential therapies for a variety of important human diseases.

MeSH Terms
Fibrosis/genetics,immunology,pathology,therapy Humans Immunity/immunology Inflammation Mediators/metabolism Myofibroblasts/metabolism,pathology Translational Research, Biomedical Wound Healing
Chemicals
Inflammation Mediators
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wynn Thomas A
Immunopathogenesis Section, Program in Barrier Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. [email protected]
Ramalingam Thirumalai R
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Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1546-170X
DOI
10.1038/nm.2807
Email
[email protected]
Published
2012-07-06
Epub
2012-00-06
Pages
1028-40
Language
English
Region
United States
NLM ID
9502015
PMCID
PMC3405917
Subset
IM
Grants
Intramural NIH HHS · ZIA AI001019-03 · United States
Intramural NIH HHS · ZIA AI001019-04 · United States
Intramural NIH HHS · ZIA AI001019-05 · United States
External Links
PubMed source DOI: 10.1038/nm.2807 PMC Full Text View journal details
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