FOXOphagy path to inducing stress resistance and cell survival.

Nature cell biology ·Vol. 14 ·No. 8 ·2012-08-00 ·Pages 786-8

Sandri M

Abstract

Nutrient deprivation and other stress stimuli elicit metabolic changes (such as the induction of autophagy and activation of FOXO transcription factors) that help an organism adapt to stressful conditions. A link between these stress response pathways is revealed by the finding that FOXO3 upregulates the expression of glutamine synthetase to promote glutamine accumulation, inhibit mTOR signalling and promote autophagy.

MeSH Terms

3-Phosphoinositide-Dependent Protein Kinases Animals Autophagy Forkhead Box Protein O3 Forkhead Transcription Factors/metabolism Glutamine/metabolism Humans Phosphatidylinositol 3-Kinases/metabolism Protein Serine-Threonine Kinases/metabolism

Chemicals

FOXO3 protein, human Forkhead Box Protein O3 Forkhead Transcription Factors Glutamine 3-Phosphoinositide-Dependent Protein Kinases Protein Serine-Threonine Kinases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Sandri Marco

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19 references, click to expand

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Article Info

Journal

Nature cell biology

Abbr.

Nat Cell Biol

ISSN

1476-4679

DOI

10.1038/ncb2550

Published

2012-08-00

Pages

786-8

Language

English

Region

England

NLM ID

100890575

Subset

Grants

Telethon · TCR09003 · Italy

Corrections

CommentOn

PMID: 22820375

External Links

PubMed source DOI: 10.1038/ncb2550 View journal details

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FOXOphagy path to inducing stress resistance and cell survival.

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