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PMID: 228588 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The TO strains of Theiler's viruses cause "slow virus-like" infections in mice.

Annals of neurology ·Vol. 6 ·No. 1 ·1979-07-00 ·Pages 25-8

Lipton HL, Dal Canto MC

Abstract

Intracerebral inoculation of mice with tissue culture-adapted TO strains of Theiler's mouse encephalomyelitis viruses results in a clinical disease consisting of spastic paralysis due to demyelination after a lengthy incubation period. Thus, in effect, these ordinary picornaviruses are capable of causing a slow infection in their natural host, the mouse. In addition, through the use of tissue culture-adapted virus stocks, virus content in mouse tissues now can be accurately quantified by standard plaque assay.

MeSH Terms

Animals Enterovirus Male Maus Elberfeld virus Mice Picornaviridae Slow Virus Diseases/etiology,pathology Virus Diseases/pathology

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lipton H L

Dal Canto M C

References (19)

19 references, click to expand

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Article Info

Journal

Annals of neurology

Abbr.

Ann Neurol

ISSN

0364-5134

DOI

10.1002/ana.410060106

Published

1979-07-00

Pages

25-8

Language

English

Region

United States

NLM ID

7707449

PMCID

PMC7159513

Subset

External Links

PubMed source DOI: 10.1002/ana.410060106 PMC Full Text View journal details

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The TO strains of Theiler's viruses cause "slow virus-like" infections in mice.

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