Cell biology. An ancient portal to proteolysis.

Science (New York, N.Y.) ·Vol. 337 ·No. 6096 ·2012-08-17 ·Pages 813-4

Matouschek A, Finley D

Abstract

暂无摘要

MeSH Terms

Adenosine Triphosphatases/metabolism Archaeal Proteins/metabolism Cell Cycle Proteins/metabolism Proteasome Endopeptidase Complex/metabolism Proteolysis Thermoplasma/enzymology Valosin Containing Protein

Chemicals

Archaeal Proteins Cell Cycle Proteins Proteasome Endopeptidase Complex Adenosine Triphosphatases Valosin Containing Protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Matouschek Andreas

Department of Chemistry and Biochemistry and Section of Molecular Genetics and Microbiology, University of Texas, Austin, TX 78712, USA. [email protected]

Finley Daniel

References (17)

17 references, click to expand

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.
Nature. 2001 Dec 6;414(6864):652-6 PMID: 11740563
Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation.
Proc Natl Acad Sci U S A. 2007 May 22;104(21):8785-90 PMID: 17496150
Complete subunit architecture of the proteasome regulatory particle.
Nature. 2012 Jan 11;482(7384):186-91 PMID: 22237024
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.
Nat Cell Biol. 2012 Feb 02;14(2):117-23 PMID: 22298039
Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii.
Nature. 2010 Jan 7;463(7277):54-60 PMID: 20054389
Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.
Science. 2008 Nov 14;322(5904):1104-7 PMID: 18832610
Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk.
Mol Cell. 2001 Aug;8(2):439-48 PMID: 11545745
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine.
Science. 2012 Aug 17;337(6096):843-6 PMID: 22837385
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.
J Mol Biol. 2009 Dec 11;394(4):732-46 PMID: 19782090
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
Cell. 2008 Sep 5;134(5):804-16 PMID: 18775313
Recognition and processing of ubiquitin-protein conjugates by the proteasome.
Annu Rev Biochem. 2009;78:477-513 PMID: 19489727
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.
Nat Cell Biol. 2002 Feb;4(2):134-9 PMID: 11813000
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.
Mol Cell. 2007 Sep 7;27(5):731-44 PMID: 17803938
Structure and evolution of ubiquitin and ubiquitin-related domains.
Methods Mol Biol. 2012;832:15-63 PMID: 22350875
Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding.
Mol Cell Biol. 2011 Apr;31(7):1528-39 PMID: 21282470
A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting.
Cell. 2005 Jan 14;120(1):73-84 PMID: 15652483
Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii.
Mol Cell. 2009 May 14;34(4):473-84 PMID: 19481527

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1227301

[email protected]

Published

2012-08-17

Pages

813-4

Language

English

Region

United States

NLM ID

0404511

PMCID

PMC3581351

Subset

Grants

NIGMS NIH HHS · R37 GM043601 · United States

NCI NIH HHS · U54 CA143869 · United States

Corrections

CommentOn

PMID: 22837385

External Links

PubMed source DOI: 10.1126/science.1227301 PMC Full Text View journal details

Analysis Services

Cell biology. An ancient portal to proteolysis.

Contact

WeChat Official Account