Abstract
Supplemental dietary arginine has anti-tumor properties but the degree and mechanisms are unclear. In non-tumor-bearing CBA/J mice (n = 60), 1% arginine supplementation significantly enhanced thymic weight, spleen cell mitogenesis, and interferon-activated natural killer cell activity; no further enhancement was observed with 2% or 4% supplementation. Supplemental 1% arginine, when compared with 1.7% glycine, enhanced interferon-induced natural killer cell activity, lymphokine-activated killer cell generation, and macrophage cytotoxicity. In A/J mice (n = 420), bearing either a moderately immunogenic (C1300) or weakly immunogenic (TBJ) murine neuroblastoma, 1% arginine significantly (p less than 0.05) retarded tumor growth and prolonged median survival time compared with glycine or no supplementation. Dietary arginine enhanced T-cell function and significantly increased responsiveness to autologous C1300 tumor in a mixed lymphocyte tumor cell culture (MLTC). The immunomodulatory effects of arginine provide nutritional and immunologic support of the tumor-bearing host and may be helpful when given concommitant with immunotherapy.
MeSH Terms
Animals
Arginine/administration & dosage,pharmacology
Cytotoxicity, Immunologic
Diet
Dose-Response Relationship, Drug
Glycine/pharmacology
Killer Cells, Lymphokine-Activated/immunology
Killer Cells, Natural/immunology
Lymphocyte Activation/drug effects
Lymphoma/immunology
Macrophages/immunology
Male
Mice
Mice, Inbred Strains
Neuroblastoma/immunology
Chemicals
Arginine
Glycine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Reynolds J V
Division of Surgical Oncology, University of Pennsylvania, Philadelphia 19104.
Daly J M
Shou J
Sigal R
Ziegler M M
Naji A
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