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PMID: 2304139 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Simian immunodeficiency viruses from African green monkeys display unusual genetic diversity.

Journal of virology ·Vol. 64 ·No. 3 ·1990-03-00 ·Pages 1086-92

Johnson PR, Fomsgaard A, Allan J, Gravell M, London WT, Olmsted RA, Hirsch VM

Abstract

African green monkeys are asymptomatic carriers of simian immunodeficiency viruses (SIV), commonly called SIVagm. As many as 50% of African green monkeys in the wild may be SIV seropositive. This high seroprevalence rate and the potential for genetic variation of lentiviruses suggested to us that African green monkeys may harbor widely differing genotypes of SIVagm. To investigate this hypothesis, we determined the entire nucleotide sequence of an infectious proviral molecular clone of SIVagm (155-4) and partial sequences (long terminal repeat and Gag) of three other distinct SIVagm isolates (90, gri-1, and ver-1). Comparisons among the SIVagm isolates revealed extreme diversity at the nucleotide and amino acid levels. Long terminal repeat nucleotide sequences varied up to 35% and Gag protein sequences varied up to 30%. The variability among SIVagm isolates exceeded the variability among any other group of primate lentiviruses. Our data suggest that SIVagm has been in the African green monkey population for a long time and may be the oldest primate lentivirus group in existence.

MeSH Terms
Amino Acids/analysis Animals Base Sequence Biological Evolution Cercopithecus/microbiology Chlorocebus aethiops/microbiology Cloning, Molecular DNA, Viral/genetics Genes, Viral Genetic Variation HIV/genetics Molecular Sequence Data Oligonucleotide Probes Repetitive Sequences, Nucleic Acid Sequence Homology, Nucleic Acid Simian Immunodeficiency Virus/classification,genetics,isolation & purification Viral Envelope Proteins/genetics Viral Proteins/genetics
Chemicals
Amino Acids DNA, Viral Oligonucleotide Probes Viral Envelope Proteins Viral Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Johnson P R
Department of Microbiology, Georgetown University, Rockville, Maryland 20852.
Fomsgaard A
Allan J
Gravell M
London W T
Olmsted R A
Hirsch V M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.64.3.1086-1092.1990
Published
1990-03-00
Pages
1086-92
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC249221
Subset
IM
Grants
NIAID NIH HHS · N01-AI-72623 · United States
Databases
GENBANK
M29973, M29974, M29975, M33718, M33719
External Links
PubMed source DOI: 10.1128/JVI.64.3.1086-1092.1990 PMC Full Text View journal details
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