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PMID: 23076053 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells.

Cell adhesion & migration ·Vol. 6 ·No. 5 ·2012-00-00 ·Pages 409-12

Thapa N, Anderson RA

Abstract

Cell migration is a fundamental cellular process required for embryonic development to wound healing and also plays a key role in tumor metastasis and atherosclerosis. Migration is regulated at multiple strata, from cytoskeletal reorganization to vesicle trafficking. In migrating cells, signaling pathways are integrated with vesicle trafficking machineries in a highly coordinated fashion to accomplish the recruitment and trafficking of the trans-membrane proteins toward the leading edge. Different signaling molecules regulate cell migration in different physio-pathological contexts, among them, phosphatidylinositol-4,5-biphosphate (PIP2) is an integral component of the plasma membrane and pleiotropic lipid signaling molecule modulating diverse biological processes, including actin cytoskeletal dynamics and vesicle trafficking required for cell migration. In this commentary, we provide a brief overview of our current understandings on the phosphoinositide signaling and its implication in regulation of cell polarity and vesicle trafficking in migrating cells. In addition, we highlight the coordinated role of PIPKIγi2, a focal adhesion-targeted enzyme that synthesizes PIP2, and the exocyst complex, a PIP2-effector, in the trafficking of E-cadherin in epithelial cells and integrins in migrating cancer cells.

MeSH Terms
Cadherins/metabolism Cell Adhesion Cell Movement Cell Polarity Epithelial Cells/metabolism Exocytosis Focal Adhesions/metabolism Humans Integrin beta Chains/metabolism Integrin beta1/metabolism Multiprotein Complexes/metabolism Neoplasms/metabolism,pathology Phosphatidylinositol 4,5-Diphosphate/metabolism Protein Transport Signal Transduction Transport Vesicles/metabolism
Chemicals
Cadherins Integrin beta Chains Integrin beta1 Multiprotein Complexes Phosphatidylinositol 4,5-Diphosphate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Thapa Narendra
Molecular and Cellular Pharmacology Program, School of Medicine and Public Health, University of Wisconsin-Madison; Madison, WI, USA.
Anderson Richard A
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Article Info
Journal
Cell adhesion & migration
Abbr.
Cell Adh Migr
ISSN
1933-6926
DOI
10.4161/cam.21192
Published
2012-00-00
Epub
2012-00-01
Pages
409-12
Language
English
Region
United States
NLM ID
101469464
PMCID
PMC3496677
Subset
IM
Grants
NCI NIH HHS · CA104708 · United States
NCI NIH HHS · R01 CA104708 · United States
NIGMS NIH HHS · R01 GM057549 · United States
NCI NIH HHS · P30-CA-014520 · United States
NIGMS NIH HHS · GM057549 · United States
NCI NIH HHS · P30 CA014520 · United States
External Links
PubMed source DOI: 10.4161/cam.21192 PMC Full Text View journal details
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