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PMID: 2310385 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells.

Biochemical and biophysical research communications ·Vol. 167 ·No. 1 ·1990-02-28 ·Pages 137-42

Pritchard KA, Tota RR, Stemerman MB, Wong PY

Abstract

Arachidonic acid (AA) can be metabolized in endothelial cells (EC) to a series of epoxides via cytochrome P-450 epoxygenase with 14,15 epoxyeicosatrienoic acid (14,15-EET) as the major product. In this communication we report that 14,15-EET significantly enhances U937 cell attachment to EC with maximal cell attachment at 2.5 to 5 x 10(-7) M 14,15-EET. Thus, 14,15-EET may play a substantial role in inflammation and/or atherogenesis by inducing monocyte attachment to EC.

MeSH Terms
8,11,14-Eicosatrienoic Acid/analogs & derivatives,pharmacology Cell Adhesion/drug effects Cells, Cultured Chromatography, High Pressure Liquid Endothelium/cytology,drug effects,enzymology Fatty Acids, Unsaturated/pharmacology Fluorescent Dyes Humans L-Lactate Dehydrogenase/metabolism Prostaglandins/analysis Thrombin/pharmacology Tumor Cells, Cultured
Chemicals
Fatty Acids, Unsaturated Fluorescent Dyes Prostaglandins 14,15-epoxy-5,8,11-eicosatrienoic acid L-Lactate Dehydrogenase Thrombin 8,11,14-Eicosatrienoic Acid
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Pritchard K A
Department of Physiology, New York Medical College, Valhalla 10595.
Tota R R
Stemerman M B
Wong P Y
Article Info
Journal
Biochemical and biophysical research communications
Abbr.
Biochem Biophys Res Commun
ISSN
0006-291X
DOI
10.1016/0006-291x(90)91741-a
Published
1990-02-28
Pages
137-42
Language
English
Region
United States
NLM ID
0372516
Subset
IM
Grants
NHLBI NIH HHS · HL21429 · United States
NHLBI NIH HHS · HL25316 · United States
NHLBI NIH HHS · HL33742 · United States
External Links
PubMed source DOI: 10.1016/0006-291x(90)91741-a View journal details
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