Home LiteratureArticle Details
PMID: 23109555 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The UCSC Cancer Genomics Browser: update 2013.

Nucleic acids research ·Vol. 41 ·No. Database issue ·2013-01-00 ·Pages D949-54

Goldman M, Craft B, Swatloski T, Ellrott K, Cline M, Diekhans M, Ma S, Wilks C, Stuart J, Haussler D, Zhu J

Abstract

The UCSC Cancer Genomics Browser (https://genome-cancer.ucsc.edu/) is a set of web-based tools to display, investigate and analyse cancer genomics data and its associated clinical information. The browser provides whole-genome to base-pair level views of several different types of genomics data, including some next-generation sequencing platforms. The ability to view multiple datasets together allows users to make comparisons across different data and cancer types. Biological pathways, collections of genes, genomic or clinical information can be used to sort, aggregate and zoom into a group of samples. We currently display an expanding set of data from various sources, including 201 datasets from 22 TCGA (The Cancer Genome Atlas) cancers as well as data from Cancer Cell Line Encyclopedia and Stand Up To Cancer. New features include a completely redesigned user interface with an interactive tutorial and updated documentation. We have also added data downloads, additional clinical heatmap features, and an updated Tumor Image Browser based on Google Maps. New security features allow authenticated users access to private datasets hosted by several different consortia through the public website.

MeSH Terms
Cell Line, Tumor Databases, Genetic Genomics Humans Internet Neoplasms/genetics
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Goldman Mary
Center for Biomolecular Science and Engineering, University of California at Santa Cruz, Santa Cruz, CA 95064, USA. [email protected]
Craft Brian
Swatloski Teresa
Ellrott Kyle
Cline Melissa
Diekhans Mark
Ma Singer
Wilks Chris
Stuart Josh
Haussler David
Zhu Jingchun
References (17)
17 references, click to expand
  1. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
    Cancer Cell. 2010 May 18;17(5):510-22 PMID: 20399149
  2. Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM.
    Bioinformatics. 2010 Jun 15;26(12):i237-45 PMID: 20529912
  3. Role of DNA methylation in the regulation of transcription.
    Curr Opin Genet Dev. 1994 Apr;4(2):255-9 PMID: 8032203
  4. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
    Cancer Cell. 2006 Dec;10(6):515-27 PMID: 17157791
  5. Functions of DNA methylation: islands, start sites, gene bodies and beyond.
    Nat Rev Genet. 2012 May 29;13(7):484-92 PMID: 22641018
  6. Subtype and pathway specific responses to anticancer compounds in breast cancer.
    Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2724-9 PMID: 22003129
  7. Molecular mechanisms of gene silencing mediated by DNA methylation.
    Mol Cell Biol. 2002 May;22(9):3157-73 PMID: 11940673
  8. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature. 2012 Mar 28;483(7391):603-7 PMID: 22460905
  9. I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy.
    Clin Pharmacol Ther. 2009 Jul;86(1):97-100 PMID: 19440188
  10. Hallmarks of cancer: the next generation.
    Cell. 2011 Mar 4;144(5):646-74 PMID: 21376230
  11. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers.
    Genome Biol. 2011;12(4):R41 PMID: 21527027
  12. Modelling the molecular circuitry of cancer.
    Nat Rev Cancer. 2002 May;2(5):331-41 PMID: 12044009
  13. Cancer genes and the pathways they control.
    Nat Med. 2004 Aug;10(8):789-99 PMID: 15286780
  14. Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies.
    Sci Am. 2007 Mar;296(3):50-7 PMID: 17348159
  15. Systematic identification of genomic markers of drug sensitivity in cancer cells.
    Nature. 2012 Mar 28;483(7391):570-5 PMID: 22460902
  16. The UCSC Cancer Genomics Browser.
    Nat Methods. 2009 Apr;6(4):239-40 PMID: 19333237
  17. A multigene predictor of outcome in glioblastoma.
    Neuro Oncol. 2010 Jan;12(1):49-57 PMID: 20150367
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
Published
2013-01-00
Epub
2012-00-29
Pages
D949-54
Language
English
Region
England
NLM ID
0411011
PMCID
PMC3531186
Subset
IM
Grants
NCI NIH HHS · U24 CA143858 · United States
Howard Hughes Medical Institute · United States
NCI NIH HHS · 5U24CA143858 · United States
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]