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PMID: 2327782 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification of a group of Haemophilus influenzae penicillin-binding proteins that may have complementary physiological roles.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 2 ·1990-02-00 ·Pages 363-5

Malouin F, Parr TR, Bryan LE

Abstract

[35S]penicillin bound to different Haemophilus influenzae proteins in assays performed at 20, 37, or 42 degrees C. Penicillin-binding proteins 3a, 3b, 4, and 4' formed a group characterized by their affinity for moxalactam, cefotaxime, and piperacillin. Penicillin-binding protein 4' showed specific properties that may reflect its complementary role in septation.

MeSH Terms
Bacterial Proteins Carrier Proteins/metabolism,physiology Culture Media Haemophilus influenzae/metabolism Hexosyltransferases Muramoylpentapeptide Carboxypeptidase/metabolism,physiology Penicillin G/metabolism Penicillin-Binding Proteins Penicillins/metabolism Peptidyl Transferases Spectrometry, Fluorescence Sulfur Radioisotopes Temperature
Chemicals
Bacterial Proteins Carrier Proteins Culture Media Penicillin-Binding Proteins Penicillins Sulfur Radioisotopes Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase Penicillin G
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Malouin F
Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285-0438.
Parr T R
Bryan L E
References (8)
8 references, click to expand
  1. Maturation of the head of bacteriophage T4. I. DNA packaging events.
    J Mol Biol. 1973 Nov 15;80(4):575-99 PMID: 4204102
  2. Penicillin-binding proteins in Haemophilus influenzae.
    Antimicrob Agents Chemother. 1981 Apr;19(4):584-8 PMID: 6972731
  3. Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics.
    Annu Rev Biochem. 1983;52:825-69 PMID: 6351730
  4. Haemophilus influenzae penicillin-binding proteins 1a and 3 possess distinct and opposite temperature-modulated penicillin-binding activities.
    Antimicrob Agents Chemother. 1988 Apr;32(4):498-502 PMID: 3259855
  5. Mode of action of beta-lactam antibiotics.
    Pharmacol Ther. 1985;27(1):1-35 PMID: 3889939
  6. Ampicillin resistance and penicillin-binding proteins of Haemophilus influenzae.
    J Gen Microbiol. 1986 Oct;132(10):2855-61 PMID: 3498005
  7. Genetic and phenotypic diversity among ampicillin-resistant, non-beta-lactamase-producing, nontypeable Haemophilus influenzae isolates.
    Infect Immun. 1987 Nov;55(11):2585-9 PMID: 3499396
  8. Mechanism of resistance of an ampicillin-resistant, beta-lactamase-negative clinical isolate of Haemophilus influenzae type b to beta-lactam antibiotics.
    Antimicrob Agents Chemother. 1984 Jun;25(6):747-53 PMID: 6611136
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.34.2.363
Published
1990-02-00
Pages
363-5
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC171589
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.34.2.363 PMC Full Text View journal details
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