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PMID: 23297039 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels.

Journal of the National Cancer Institute ·Vol. 105 ·No. 3 ·2013-02-06 ·Pages 175-201

Jemal A, Simard EP, Dorell C, Noone AM, Markowitz LE, Kohler B, Eheman C, Saraiya M, Bandi P, Saslow D, Cronin KA, Watson M, Schiffman M, Henley SJ, Schymura MJ, Anderson RN, Yankey D, Edwards BK

Abstract

The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate annually to provide updates on cancer incidence and death rates and trends in these outcomes for the United States. This year's report includes incidence trends for human papillomavirus (HPV)-associated cancers and HPV vaccination (recommended for adolescents aged 11-12 years). Data on cancer incidence were obtained from the CDC, NCI, and NAACCR, and data on mortality were obtained from the CDC. Long- (1975/1992-2009) and short-term (2000-2009) trends in age-standardized incidence and death rates for all cancers combined and for the leading cancers among men and among women were examined by joinpoint analysis. Prevalence of HPV vaccination coverage during 2008 and 2010 and of Papanicolaou (Pap) testing during 2010 were obtained from national surveys. Death rates continued to decline for all cancers combined for men and women of all major racial and ethnic groups and for most major cancer sites; rates for both sexes combined decreased by 1.5% per year from 2000 to 2009. Overall incidence rates decreased in men but stabilized in women. Incidence rates increased for two HPV-associated cancers (oropharynx, anus) and some cancers not associated with HPV (eg, liver, kidney, thyroid). Nationally, 32.0% (95% confidence interval [CI] = 30.3% to 33.6%) of girls aged 13 to 17 years in 2010 had received three doses of the HPV vaccine, and coverage was statistically significantly lower among the uninsured (14.1%, 95% CI = 9.4% to 20.6%) and in some Southern states (eg, 20.0% in Alabama [95% CI = 13.9% to 27.9%] and Mississippi [95% CI = 13.8% to 28.2%]), where cervical cancer rates were highest and recent Pap testing prevalence was the lowest. The overall trends in declining cancer death rates continue. However, increases in incidence rates for some HPV-associated cancers and low vaccination coverage among adolescents underscore the need for additional prevention efforts for HPV-associated cancers, including efforts to increase vaccination coverage.

MeSH Terms
Adolescent African Americans/statistics & numerical data Age Distribution Alphapapillomavirus Anus Neoplasms/epidemiology,virology Asian Americans/statistics & numerical data Cause of Death Cost of Illness Female Hispanic or Latino/statistics & numerical data Humans Incidence Indians, North American/statistics & numerical data Male Mortality/trends Native Hawaiian or Other Pacific Islander/statistics & numerical data Neoplasms/epidemiology,ethnology,mortality,prevention & control,virology Oropharyngeal Neoplasms/epidemiology,virology Papanicolaou Test Papillomavirus Infections/complications,epidemiology,ethnology Papillomavirus Vaccines/administration & dosage Penile Neoplasms/epidemiology,virology SEER Program Sex Distribution United States/epidemiology Uterine Cervical Neoplasms/epidemiology,virology Vaginal Neoplasms/epidemiology,virology Vaginal Smears/statistics & numerical data Vulvar Neoplasms/epidemiology,virology
Chemicals
Papillomavirus Vaccines
Authors & Affiliations
18 authors, click to expand affiliations / ORCID
Jemal Ahmedin
Surveillance Research Program, American Cancer Society, 250 Williams St NW, Atlanta, GA 30303, USA. [email protected]
Simard Edgar P
Dorell Christina
Noone Anne-Michelle
Markowitz Lauri E
Kohler Betsy
Eheman Christie
Saraiya Mona
Bandi Priti
Saslow Debbie
Cronin Kathleen A
Watson Meg
Schiffman Mark
Henley S Jane
Schymura Maria J
Anderson Robert N
Yankey David
Edwards Brenda K
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Article Info
Journal
Journal of the National Cancer Institute
Abbr.
J Natl Cancer Inst
ISSN
1460-2105
DOI
10.1093/jnci/djs491
Email
[email protected]
Published
2013-02-06
Epub
2013-00-07
Pages
175-201
Language
English
Region
United States
NLM ID
7503089
PMCID
PMC3565628
Subset
IM
Corrections
CommentIn
PMID: 23297040
CommentIn
PMID: 23641042
External Links
PubMed source DOI: 10.1093/jnci/djs491 PMC Full Text View journal details
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