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PMID: 23478666 Published · ppublish English Letter Research Support, Non-U.S. Gov't

A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice.

Leukemia ·Vol. 27 ·No. 9 ·2013-09-00 ·Pages 1917-20

Mupo A, Celani L, Dovey O, Cooper JL, Grove C, Rad R, Sportoletti P, Falini B, Bradley A, Vassiliou GS

Abstract

暂无摘要

MeSH Terms

Animals Cell Transformation, Neoplastic/genetics Disease Models, Animal Epistasis, Genetic Leukemia, Myeloid, Acute/genetics,metabolism Mice Mice, Knockout Mutation Nuclear Proteins/genetics,metabolism Nucleophosmin Tandem Repeat Sequences fms-Like Tyrosine Kinase 3/genetics,metabolism

Chemicals

Nuclear Proteins Nucleophosmin Flt3 protein, mouse fms-Like Tyrosine Kinase 3

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Mupo A

Celani L

Dovey O

Cooper J L

Grove C

Rad R

Sportoletti P

Falini B

Bradley A

Vassiliou G S

References (15)

15 references, click to expand

Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.
Nucleic Acids Res. 2004 Jul 01;32(11):e92 PMID: 15247325
The origin and evolution of mutations in acute myeloid leukemia.
Cell. 2012 Jul 20;150(2):264-78 PMID: 22817890
The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia.
Blood. 2006 Aug 1;108(3):1030-6 PMID: 16861351
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
N Engl J Med. 2012 Mar 22;366(12):1079-89 PMID: 22417203
Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications.
Leukemia. 2009 Oct;23(10):1731-43 PMID: 19516275
Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.
Cancer Res. 2001 Oct 1;61(19):7233-9 PMID: 11585760
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.
Nature. 2012 Aug 30;488(7413):656-9 PMID: 22763442
FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.
Cancer Cell. 2007 Oct;12(4):367-80 PMID: 17936561
Mapping the functional domains of nucleolar protein B23.
J Biol Chem. 2000 Aug 11;275(32):24451-7 PMID: 10829026
Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product.
Leukemia. 1998 Sep;12(9):1333-7 PMID: 9737679
Independent prognostic factors for AML outcome.
Hematology Am Soc Hematol Educ Program. 2009;:385-95 PMID: 20008224
Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.
Oncogene. 2002 Apr 11;21(16):2555-63 PMID: 11971190
Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.
Blood. 2012 Mar 22;119(12):2883-94 PMID: 22323452
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.
Nat Genet. 2011 May;43(5):470-5 PMID: 21441929
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
N Engl J Med. 2005 Jan 20;352(3):254-66 PMID: 15659725

Article Info

Journal

Leukemia

Abbr.

Leukemia

ISSN

1476-5551

DOI

10.1038/leu.2013.77

Published

2013-09-00

Epub

2013-00-12

Pages

1917-20

Language

English

Region

England

NLM ID

8704895

PMCID

PMC3768110

Subset

Grants

Wellcome Trust · 095663 · United Kingdom

External Links

PubMed source DOI: 10.1038/leu.2013.77 PMC Full Text View journal details

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A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice.

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