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PMID: 23524462 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

T cell receptor signalling networks: branched, diversified and bounded.

Nature reviews. Immunology ·Vol. 13 ·No. 4 ·2013-04-00 ·Pages 257-69

Brownlie RJ, Zamoyska R

Abstract

Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation. Acquisition of appropriate effector T cell function requires the participation of multiple signals from the T cell microenvironment. Trying to understand how these signals integrate to achieve specific functional outcomes while maintaining tolerance to self is a major challenge in lymphocyte biology. Several recent publications have provided important insights into how dysregulation of T cell signalling and the development of autoreactivity can result if the branching and integration of signalling pathways are perturbed. We discuss how these findings highlight the importance of spatial segregation of individual signalling components as a way of regulating T cell responsiveness and immune tolerance.

MeSH Terms
Humans Immune Tolerance/immunology Integrins/immunology,metabolism Lymphocyte Activation/immunology Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/immunology,metabolism Models, Immunological Receptors, Antigen, T-Cell/immunology,metabolism Signal Transduction/immunology T-Lymphocytes/immunology,metabolism
Chemicals
Integrins Receptors, Antigen, T-Cell Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Brownlie Rebecca J
Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh EH9 3JT, UK.
Zamoyska Rose
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3403
Published
2013-04-00
Pages
257-69
Language
English
Region
England
NLM ID
101124169
Subset
IM
Grants
Wellcome Trust · 096669 · United Kingdom
External Links
PubMed source DOI: 10.1038/nri3403 View journal details
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