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PMID: 2357850 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) hy human monocytes.

Clinical and experimental immunology ·Vol. 80 ·No. 2 ·1990-05-00 ·Pages 232-5

Ferrante A, Seow WK, Rowan-Kelly B, Thong YH

Abstract

Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concentration range of 0.1 to 5 micrograms/ml. Tetrandrine may be potentially useful in the treatment of inflammatory diseases in which TNF-alpha plays a major role.

MeSH Terms
Alkaloids/pharmacology Anti-Inflammatory Agents, Non-Steroidal/pharmacology Benzylisoquinolines Cells, Cultured Humans Monocytes/drug effects,metabolism Tumor Necrosis Factor-alpha/biosynthesis
Chemicals
Alkaloids Anti-Inflammatory Agents, Non-Steroidal Benzylisoquinolines Tumor Necrosis Factor-alpha tetrandrine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ferrante A
Department of Immunology, Adelaide Children's Hospital, Australia.
Seow W K
Rowan-Kelly B
Thong Y H
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
DOI
10.1111/j.1365-2249.1990.tb05239.x
Published
1990-05-00
Pages
232-5
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1535282
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2249.1990.tb05239.x PMC Full Text View journal details
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