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PMID: 2357960 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Differences in glycoprotein complexes associated with IgM and IgD on normal murine B cells potentially enable transduction of different signals.

The EMBO journal ·Vol. 9 ·No. 7 ·1990-07-00 ·Pages 2117-24

Chen JZ, Stall AM, Herzenberg LA, Herzenberg LA

Abstract

Studies presented here demonstrate that IgM and IgD molecules on normal murine B lymphocytes exist in different, noncovalently associated molecular complexes containing distinct but potentially related glycoproteins. The glycoproteins in these complexes, particularly those associated with IgD, show striking differences in various lymphoid organs and in X-linked immunodeficient (Xid) mice. These differences are due in part to post-translational processing. They apparently reflect the differential expression of the Ig-associated glycoproteins in the various B cell subpopulations and lineages and the differential distribution of the subpopulations and lineages in the various lymphoid organs. In addition, they reflect structural differences in the IgM and IgD complexes which, we suggest, permit differential signal transduction by IgM and IgD on the same B cell.

MeSH Terms
Animals B-Lymphocytes/immunology Electrophoresis, Polyacrylamide Gel Immunoglobulin D/isolation & purification,physiology Immunoglobulin M/isolation & purification,physiology Lymph Nodes/immunology Membrane Glycoproteins/isolation & purification,physiology Mice Mice, Inbred BALB C Mice, Inbred CBA Molecular Weight Peritoneal Cavity/cytology Protein Binding Receptors, Antigen, B-Cell/isolation & purification,physiology Signal Transduction Spleen/immunology
Chemicals
Immunoglobulin D Immunoglobulin M Membrane Glycoproteins Receptors, Antigen, B-Cell
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chen J Z
Department of Genetics, Stanford University School of Medicine, CA 94305.
Stall A M
Herzenberg L A
Herzenberg L A
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1990-07-00
Pages
2117-24
Language
English
Region
England
NLM ID
8208664
PMCID
PMC551931
Subset
IM
Grants
NCI NIH HHS · CA 42509 · United States
NICHD NIH HHS · HD 01287 · United States
External Links
PubMed source PMC Full Text View journal details
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