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PMID: 23587058 Published · epublish English Journal Article

The sequence and analysis of a Chinese pig genome.

GigaScience ·Vol. 1 ·No. 1 ·2012-11-15 ·Pages 16

Fang X, Mou Y, Huang Z, Li Y, Han L, Zhang Y, Feng Y, Chen Y, Jiang X, Zhao W, Sun X, Xiong Z, Yang L, Liu H, Fan D, Mao L, Ren L, Liu C, Wang J, Li K, Wang G, Yang S, Lai L, Zhang G, Li Y, Wang J, Bolund L, Yang H, Wang J, Feng S, Li S, Du Y

Abstract

The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as an important model organism because of their similarity to humans at the anatomical, physiological and genetic level, making them very useful for studying a variety of human diseases. A pig strain of particular interest is the miniature pig, specifically the Wuzhishan pig (WZSP), as it has been extensively inbred. Its high level of homozygosity offers increased ease for selective breeding for specific traits and a more straightforward understanding of the genetic changes that underlie its biological characteristics. WZSP also serves as a promising means for applications in surgery, tissue engineering, and xenotransplantation. Here, we report the sequencing and analysis of an inbreeding WZSP genome. Our results reveal some unique genomic features, including a relatively high level of homozygosity in the diploid genome, an unusual distribution of heterozygosity, an over-representation of tRNA-derived transposable elements, a small amount of porcine endogenous retrovirus, and a lack of type C retroviruses. In addition, we carried out systematic research on gene evolution, together with a detailed investigation of the counterparts of human drug target genes. Our results provide the opportunity to more clearly define the genomic character of pig, which could enhance our ability to create more useful pig models.

Authors & Affiliations
32 authors, click to expand affiliations / ORCID
Fang Xiaodong
BGI-Shenzhen, Bei Shan Road, Yantian, Shenzhen, 518083, China. [email protected].
Mou Yulian
Huang Zhiyong
Li Yong
Han Lijuan
Zhang Yanfeng
Feng Yue
Chen Yuanxin
Jiang Xuanting
Zhao Wei
Sun Xiaoqing
Xiong Zhiqiang
Yang Lan
Liu Huan
Fan Dingding
Mao Likai
Ren Lijie
Liu Chuxin
Wang Juan
Li Kui
Wang Guangbiao
Yang Shulin
Lai Liangxue
Zhang Guojie
Li Yingrui
Wang Jun
Bolund Lars
Yang Huanming
Wang Jian
Feng Shutang
Li Songgang
Du Yutao
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Article Info
Journal
GigaScience
Abbr.
Gigascience
ISSN
2047-217X
DOI
10.1186/2047-217X-1-16
Email
[email protected]
Published
2012-11-15
Epub
2012-00-15
Pages
16
Language
English
Region
United States
NLM ID
101596872
PMCID
PMC3626506
External Links
PubMed source DOI: 10.1186/2047-217X-1-16 PMC Full Text View journal details
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