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PMID: 23664821 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Neural structures underlying set-shifting: roles of medial prefrontal cortex and anterior cingulate cortex.

Behavioural brain research ·Vol. 250 ·2013-08-01 ·Pages 91-101

Bissonette GB, Powell EM, Roesch MR

Abstract

Impaired attentional set-shifting and inflexible decision-making are problems frequently observed during normal aging and in several psychiatric disorders. To understand the neuropathophysiology of underlying inflexible behavior, animal models of attentional set-shifting have been developed to mimic tasks such as the Wisconsin Card Sorting Task (WCST), which tap into a number of cognitive functions including stimulus-response encoding, working memory, attention, error detection, and conflict resolution. Here, we review many of these tasks in several different species and speculate on how prefrontal cortex and anterior cingulate cortex might contribute to normal performance during set-shifting.

MeSH Terms
Animals Attention/physiology Attention Deficit Disorder with Hyperactivity/pathology Disease Models, Animal Gyrus Cinguli/physiology Humans Prefrontal Cortex/physiology Set, Psychology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bissonette Gregory B
Department of Psychology, University of Maryland, 1148 Biology-Psychology Building, College Park, MD, United States. [email protected]
Powell Elizabeth M
Roesch Matthew R
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Article Info
Journal
Behavioural brain research
Abbr.
Behav Brain Res
ISSN
1872-7549
DOI
10.1016/j.bbr.2013.04.037
Email
[email protected]
Published
2013-08-01
Epub
2013-00-09
Pages
91-101
Language
English
Region
Netherlands
NLM ID
8004872
PMCID
PMC3708542
Subset
IM
Grants
NIDA NIH HHS · R01 DA031695 · United States
NIDA NIH HHS · R01DA031695 · United States
External Links
PubMed source DOI: 10.1016/j.bbr.2013.04.037 PMC Full Text View journal details
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