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PMID: 2372251 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Intranasal immunization of mice with recombinant protein antigen of serotype c Streptococcus mutans and cholera toxin B subunit.

Archives of oral biology ·Vol. 35 ·No. 6 ·1990-00-00 ·Pages 475-7

Takahashi I, Okahashi N, Kanamoto T, Asakawa H, Koga T

Abstract

The cholera toxin subunit and the recombinant cell-surface antigen (molecular mass of 190,000 Da) were administered intranasally to BALB/c mice. After 30 days, the mice were immunized intranasally with the recombinant protein antigen alone. High serum IgG and salivary IgA responses to the protein antigen were induced by the intranasal immunization.

MeSH Terms

Administration, Intranasal Animals Antigens, Bacterial/administration & dosage Cholera Toxin/administration & dosage Female Immunization Immunoglobulin A, Secretory/analysis Immunoglobulin G/analysis Mice Mice, Inbred BALB C Recombinant Proteins/administration & dosage Serotyping Streptococcus mutans/classification,immunology

Chemicals

Antigens, Bacterial Immunoglobulin A, Secretory Immunoglobulin G Recombinant Proteins Cholera Toxin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Takahashi I

Department of Dental Research, National Institute of Health, Tokyo, Japan.

Okahashi N

Kanamoto T

Asakawa H

Koga T

Article Info

Journal

Archives of oral biology

Abbr.

Arch Oral Biol

ISSN

0003-9969

DOI

10.1016/0003-9969(90)90211-r

Published

1990-00-00

Pages

475-7

Language

English

Region

England

NLM ID

0116711

Subset

External Links

PubMed source DOI: 10.1016/0003-9969(90)90211-r View journal details

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Intranasal immunization of mice with recombinant protein antigen of serotype c Streptococcus mutans and cholera toxin B subunit.

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