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PMID: 2374589 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.

Nature ·Vol. 346 ·No. 6281 ·1990-07-19 ·Pages 245-50

Gubbay J, Collignon J, Koopman P, Capel B, Economou A, Münsterberg A, Vivian N, Goodfellow P, Lovell-Badge R

Abstract

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Chromosome Deletion Chromosome Mapping Cloning, Molecular DNA-Binding Proteins/genetics Female Male Mice Molecular Sequence Data Mutation Nucleic Acid Hybridization Restriction Mapping Sequence Homology, Nucleic Acid Sex Determination Analysis Testis/embryology,metabolism Y Chromosome
Chemicals
DNA-Binding Proteins
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Gubbay J
Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK.
Collignon J
Koopman P
Capel B
Economou A
Münsterberg A
Vivian N
Goodfellow P
Lovell-Badge R
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/346245a0
Published
1990-07-19
Pages
245-50
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
Medical Research Council · MC_U117562207 · United Kingdom
Corrections
CommentIn
PMID: 2374582
External Links
PubMed source DOI: 10.1038/346245a0 View journal details
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