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PMID: 2393285 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Eradication of Helicobacter mustelae from the ferret stomach: an animal model of Helicobacter (Campylobacter) pylori chemotherapy.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 6 ·1990-06-00 ·Pages 1232-6

Otto G, Fox JG, Wu PY, Taylor NS

Abstract

Colonization of the ferret stomach by Helicobacter mustelae has been suggested as a possible animal model for Helicobacter pylori-associated gastroduodenal disease of humans. Our study was designed to determine whether antimicrobial chemotherapy could eradicate H. mustelae from ferrets. Triple antimicrobial therapy combining amoxicillin, metronidazole, and bismuth subsalicylate was successful in eradicating the organism from 5 of 7 (71%) adult ferrets. Despite apparent in vitro susceptibility, neither chloramphenicol monotherapy nor a polytherapeutic regimen combining tetracycline, metronidazole, and bismuth subsalicylate proved effective in the eradication of H. mustelae. Several strains isolated after unsuccessful polytherapy showed markedly increased resistance to metronidazole. These preliminary findings are similar to results of H. pylori treatment trials with humans and suggest that the ferret may be a useful model for evaluating and comparing potential antimicrobial modalities for the eradication of H. pylori.

MeSH Terms
Animals Anti-Bacterial Agents/therapeutic use Campylobacter/drug effects Campylobacter Infections/drug therapy Carnivora/microbiology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Ferrets/microbiology Gastroscopy Microbial Sensitivity Tests Stomach/microbiology Urease/analysis
Chemicals
Anti-Bacterial Agents Urease
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Otto G
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
Fox J G
Wu P Y
Taylor N S
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28 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.34.6.1232
Published
1990-06-00
Pages
1232-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC171790
Subset
IM
Grants
NCI NIH HHS · P01-CA28842 · United States
NCRR NIH HHS · RR01046 · United States
NCRR NIH HHS · T32-RR07036 · United States
External Links
PubMed source DOI: 10.1128/AAC.34.6.1232 PMC Full Text View journal details
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