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PMID: 23939028 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29.

Autophagy ·Vol. 9 ·No. 10 ·2013-10-00 ·Pages 1467-74

Chew LH, Setiaputra D, Klionsky DJ, Yip CK

Abstract

Atg17, in complex with Atg29 and Atg31, constitutes a key module of the Atg1 kinase signaling complex and functions as an important organizer of the phagophore assembly site in the yeast Saccharomyces cerevisiae. We have determined the three-dimensional reconstruction of the full S. cerevisiae Atg17-Atg31-Atg29 complex by single-particle electron microscopy. Our structure shows that Atg17-Atg31-Atg29 is dimeric and adopts a relatively rigid and extended "S-shape" architecture with an end-to-end distance of approximately 345 Å. Subunit mapping analysis indicated that Atg17 mediates dimerization and generates a central rod-like scaffold, while Atg31 and Atg29 form two globular domains that are tethered to the concave sides of the scaffold at the terminal regions. Finally, our observation that Atg17 adopts multiple conformations in the absence of Atg31 and Atg29 suggests that the two smaller components play key roles in defining and maintaining the distinct curvature of the ternary complex.

Keywords
Atg17 Atg29 Atg31 autophagy single-particle electron microscopy
MeSH Terms
Autophagy/physiology Autophagy-Related Proteins Carrier Proteins/metabolism Microscopy, Electron/methods Saccharomyces cerevisiae/cytology,metabolism Saccharomyces cerevisiae Proteins/metabolism Ternary Complex Factors/metabolism
Chemicals
ATG29 protein, S cerevisiae Atg17 protein, S cerevisiae Atg31 protein, S cerevisiae Autophagy-Related Proteins Carrier Proteins Saccharomyces cerevisiae Proteins Ternary Complex Factors
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chew Leon H
Department of Biochemistry and Molecular Biology; The University of British Columbia; Vancouver, British Columbia Canada.
Setiaputra Dheva
Department of Biochemistry and Molecular Biology; The University of British Columbia; Vancouver, British Columbia Canada.
Klionsky Daniel J
Life Sciences Institute; University of Michigan; Ann Arbor, MI USA.
Yip Calvin K
Department of Biochemistry and Molecular Biology; The University of British Columbia; Vancouver, British Columbia Canada.
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Article Info
Journal
Autophagy
Abbr.
Autophagy
ISSN
1554-8635
Published
2013-10-00
Epub
2013-00-05
Pages
1467-74
Language
English
Region
United States
NLM ID
101265188
PMCID
PMC5871871
Subset
IM
Grants
NIGMS NIH HHS · R01 GM053396 · United States
CIHR · Canada
NIGMS NIH HHS · GM053396 · United States
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