Abstract
Atg17, in complex with Atg29 and Atg31, constitutes a key module of the Atg1 kinase signaling complex and functions as an important organizer of the phagophore assembly site in the yeast Saccharomyces cerevisiae. We have determined the three-dimensional reconstruction of the full S. cerevisiae Atg17-Atg31-Atg29 complex by single-particle electron microscopy. Our structure shows that Atg17-Atg31-Atg29 is dimeric and adopts a relatively rigid and extended "S-shape" architecture with an end-to-end distance of approximately 345 Å. Subunit mapping analysis indicated that Atg17 mediates dimerization and generates a central rod-like scaffold, while Atg31 and Atg29 form two globular domains that are tethered to the concave sides of the scaffold at the terminal regions. Finally, our observation that Atg17 adopts multiple conformations in the absence of Atg31 and Atg29 suggests that the two smaller components play key roles in defining and maintaining the distinct curvature of the ternary complex.
Keywords
Atg17
Atg29
Atg31
autophagy
single-particle electron microscopy
MeSH Terms
Autophagy/physiology
Autophagy-Related Proteins
Carrier Proteins/metabolism
Microscopy, Electron/methods
Saccharomyces cerevisiae/cytology,metabolism
Saccharomyces cerevisiae Proteins/metabolism
Ternary Complex Factors/metabolism
Chemicals
ATG29 protein, S cerevisiae
Atg17 protein, S cerevisiae
Atg31 protein, S cerevisiae
Autophagy-Related Proteins
Carrier Proteins
Saccharomyces cerevisiae Proteins
Ternary Complex Factors
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chew Leon H
Department of Biochemistry and Molecular Biology; The University of British Columbia; Vancouver, British Columbia Canada.
Setiaputra Dheva
Department of Biochemistry and Molecular Biology; The University of British Columbia; Vancouver, British Columbia Canada.
Klionsky Daniel J
Life Sciences Institute; University of Michigan; Ann Arbor, MI USA.
Yip Calvin K
Department of Biochemistry and Molecular Biology; The University of British Columbia; Vancouver, British Columbia Canada.
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