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PMID: 2403115 Published · ppublish English Journal Article

Does nondifferential misclassification of exposure always bias a true effect toward the null value?

American journal of epidemiology ·Vol. 132 ·No. 4 ·1990-10-00 ·Pages 746-8

Dosemeci M, Wacholder S, Lubin JH

Abstract

The authors present some examples to demonstrate that in certain nondifferential misclassification conditions with polychotomous exposure variables, estimates of odds ratios for categories at intermediate level of risk can be biased away from the null or can change direction. In addition, the authors present two examples to demonstrate that the slope of the dose-response trend for the true distributions can change direction, creating a false inverse trend, even if the misclassification is nondifferential.

MeSH Terms
Bias Case-Control Studies Epidemiologic Methods Humans Odds Ratio
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dosemeci M
Epidemiology and Biostatistics Program, National Cancer Institute, Rockville, MD 20892.
Wacholder S
Lubin J H
Article Info
Journal
American journal of epidemiology
Abbr.
Am J Epidemiol
ISSN
0002-9262
Published
1990-10-00
Pages
746-8
Language
English
Region
United States
NLM ID
7910653
Subset
IM
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