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PMID: 24034240 Published · ppublish English Journal Article Comment

Self-eating limits EGFR-dependent tumor growth.

Cell ·Vol. 154 ·No. 6 ·2013-09-12 ·Pages 1184-6

Fantin VR, Abraham RT

Abstract

Autophagy is a cell-autonomous, catabolic process that plays context-dependent roles in tumor growth and progression. Wei et al. report that EGFR signaling promotes tumor growth through phosphorylation and functional inactivation of Beclin 1 and the consequent suppression of autophagy.

MeSH Terms
Animals Apoptosis Regulatory Proteins/metabolism Autophagy Beclin-1 Drug Resistance, Neoplasm ErbB Receptors/metabolism Humans Membrane Proteins/metabolism
Chemicals
Apoptosis Regulatory Proteins BECN1 protein, human Beclin-1 Membrane Proteins EGFR protein, human ErbB Receptors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fantin Valeria R
Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA.
Abraham Robert T
Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2013.08.040
Published
2013-09-12
Pages
1184-6
Language
English
Region
United States
NLM ID
0413066
Subset
IM
Corrections
CommentOn
PMID: 24034250
External Links
PubMed source DOI: 10.1016/j.cell.2013.08.040 View journal details
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