Home LiteratureArticle Details
PMID: 2404081 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.

The Journal of experimental medicine ·Vol. 171 ·No. 1 ·1990-01-01 ·Pages 307-14

Larsen CP, Morris PJ, Austyn JM

Abstract

It has been a long-standing dogma that host sensitization against fully-vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against fully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.

MeSH Terms
Animals Antibodies, Monoclonal Antigen-Presenting Cells/immunology,physiology Blood Volume Cell Movement Fluorescent Antibody Technique Graft Rejection Heart Transplantation/immunology,physiology Male Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred CBA Spleen/immunology Transplantation, Homologous
Chemicals
Antibodies, Monoclonal
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Larsen C P
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, United Kingdom.
Morris P J
Austyn J M
References (21)
21 references, click to expand
  1. Studies of the cells in the afferent and efferent lymph of lymph nodes draining the site of skin homografts.
    J Exp Med. 1967 May 1;125(5):737-54 PMID: 5337308
  2. The role of afferent lymphatics in the rejection of skin homografts.
    J Exp Med. 1968 Jul 1;128(1):197-221 PMID: 4873840
  3. The role of the lymphatic system in the rejection of homografts: a study of lymph from renal transplants.
    J Exp Med. 1970 May 1;131(5):936-69 PMID: 4910145
  4. Localization of afferent lymph cells within the draining node during a primary immune response.
    Nature. 1970 Aug 1;227(5257):510-3 PMID: 5428473
  5. The sensitization of rats by allografts transplanted to alymphatic pedicles of skin.
    J Exp Med. 1971 May 1;133(5):951-62 PMID: 4928819
  6. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection.
    Transplantation. 1973 Oct;16(4):343-50 PMID: 4583148
  7. Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain.
    J Exp Med. 1981 Aug 1;154(2):347-61 PMID: 6943285
  8. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.
    J Exp Med. 1982 Jan 1;155(1):31-41 PMID: 7033437
  9. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody.
    Proc Natl Acad Sci U S A. 1984 Jun;81(12):3864-8 PMID: 6427778
  10. Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells during primary antibody responses in vitro.
    J Exp Med. 1984 Sep 1;160(3):858-76 PMID: 6206192
  11. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo.
    Nature. 1984 Dec 6-12;312(5994):548-51 PMID: 6150440
  12. Massive induction of donor-type class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat.
    J Exp Med. 1985 Jan 1;161(1):98-112 PMID: 3881556
  13. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.
    J Exp Med. 1985 Mar 1;161(3):526-46 PMID: 3871837
  14. Dendritic cell-lymphoid cell aggregation and major histocompatibility antigen expression during rat cardiac allograft rejection.
    J Exp Med. 1986 Oct 1;164(4):1239-58 PMID: 3531383
  15. Survival of deoxyguanosine-treated fetal thymus allografts is prevented by priming with dendritic cells.
    Immunology. 1987 Apr;60(4):593-6 PMID: 2953671
  16. Migration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues.
    J Exp Med. 1988 Feb 1;167(2):632-45 PMID: 3258009
  17. Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone.
    J Exp Med. 1988 Feb 1;167(2):646-51 PMID: 3258010
  18. The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus.
    Cell Immunol. 1989 Jan;118(1):108-25 PMID: 2910499
  19. Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.
    J Exp Med. 1989 Mar 1;169(3):1169-78 PMID: 2522497
  20. Progressive destruction of renal homografts isolated from the regional lymphatics of the host.
    Surgery. 1955 Jul;38(1):194-214 PMID: 14396692
  21. THE ROLE OF LYMPHOCYTES IN THE SENSITIZATION OF RATS TO RENAL HOMOGRAFTS.
    J Exp Med. 1965 Aug 1;122:347-60 PMID: 14316949
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.171.1.307
Published
1990-01-01
Pages
307-14
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187651
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.171.1.307 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2