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PMID: 24043743 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology ·Vol. 31 ·No. 32 ·2013-11-10 ·Pages e439-42

van Rooij N, van Buuren MM, Philips D, Velds A, Toebes M, Heemskerk B, van Dijk LJ, Behjati S, Hilkmann H, El Atmioui D, Nieuwland M, Stratton MR, Kerkhoven RM, Kesmir C, Haanen JB, Kvistborg P, Schumacher TN

Abstract

暂无摘要

MeSH Terms
Antibodies, Monoclonal/therapeutic use Antigens, Neoplasm/immunology Antineoplastic Agents/therapeutic use DNA, Neoplasm/analysis Exome/genetics Humans Ipilimumab Lymphocytes, Tumor-Infiltrating/immunology Male Melanoma/drug therapy,genetics,immunology Middle Aged Skin Neoplasms/drug therapy,genetics,immunology T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal Antigens, Neoplasm Antineoplastic Agents DNA, Neoplasm Ipilimumab
Authors & Affiliations
17 authors, click to expand affiliations / ORCID
van Rooij Nienke
Netherlands Cancer Institute, Amsterdam, the Netherlands.
van Buuren Marit M
Philips Daisy
Velds Arno
Toebes Mireille
Heemskerk Bianca
van Dijk Laura J A
Behjati Sam
Hilkmann Henk
El Atmioui Dris
Nieuwland Marja
Stratton Michael R
Kerkhoven Ron M
Kesmir Can
Haanen John B
Kvistborg Pia
Schumacher Ton N
References (22)
22 references, click to expand
  1. Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers.
    Nat Methods. 2009 Jul;6(7):520-6 PMID: 19543285
  2. Improved survival with ipilimumab in patients with metastatic melanoma.
    N Engl J Med. 2010 Aug 19;363(8):711-23 PMID: 20525992
  3. NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11.
    Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W509-12 PMID: 18463140
  4. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
    N Engl J Med. 2012 Jun 28;366(26):2443-54 PMID: 22658127
  5. The cancer antigenome.
    EMBO J. 2013 Jan 23;32(2):194-203 PMID: 23258224
  6. Design and use of conditional MHC class I ligands.
    Nat Med. 2006 Feb;12(2):246-51 PMID: 16462803
  7. Can the exome and the immunome converge on the design of efficient cancer vaccines?
    Oncoimmunology. 2012 Aug 1;1(5):579-580 PMID: 22934249
  8. Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers.
    Nat Protoc. 2012 Apr 12;7(5):891-902 PMID: 22498709
  9. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.
    Nat Med. 2013 Jun;19(6):747-52 PMID: 23644516
  10. Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach.
    Bioinformatics. 2004 Jun 12;20(9):1388-97 PMID: 14962912
  11. Epitope landscape in breast and colorectal cancer.
    Cancer Res. 2008 Feb 1;68(3):889-92 PMID: 18245491
  12. Exome sequencing identifies GRIN2A as frequently mutated in melanoma.
    Nat Genet. 2011 May;43(5):442-6 PMID: 21499247
  13. Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab.
    Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16723-8 PMID: 21933959
  14. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
    Nat Genet. 2012 Sep;44(9):1006-14 PMID: 22842228
  15. TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.
    Oncoimmunology. 2012 Jul 1;1(4):409-418 PMID: 22754759
  16. ATR: an essential regulator of genome integrity.
    Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27 PMID: 18594563
  17. Generation of peptide-MHC class I complexes through UV-mediated ligand exchange.
    Nat Protoc. 2006;1(3):1120-32 PMID: 17406393
  18. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
    N Engl J Med. 2012 Jun 28;366(26):2455-65 PMID: 22658128
  19. The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage.
    Immunogenetics. 2005 Apr;57(1-2):33-41 PMID: 15744535
  20. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting.
    Nature. 2012 Feb 08;482(7385):400-4 PMID: 22318521
  21. A landscape of driver mutations in melanoma.
    Cell. 2012 Jul 20;150(2):251-63 PMID: 22817889
  22. Exploiting the mutanome for tumor vaccination.
    Cancer Res. 2012 Mar 1;72(5):1081-91 PMID: 22237626
Article Info
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Abbr.
J Clin Oncol
ISSN
1527-7755
DOI
10.1200/JCO.2012.47.7521
Published
2013-11-10
Epub
2013-00-16
Pages
e439-42
Language
English
Region
United States
NLM ID
8309333
PMCID
PMC3836220
Subset
IM
Grants
Wellcome Trust · 098051 · United Kingdom
Corrections
CommentIn
PMID: 24439426
External Links
PubMed source DOI: 10.1200/JCO.2012.47.7521 PMC Full Text View journal details
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