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PMID: 24090431 Published · epublish English Journal Article

SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs).

Molecular autism ·Vol. 4 ·No. 1 ·2013-10-03 ·Pages 36

Abrahams BS, Arking DE, Campbell DB, Mefford HC, Morrow EM, Weiss LA, Menashe I, Wadkins T, Banerjee-Basu S, Packer A

Abstract

New technologies enabling genome-wide interrogation have led to a large and rapidly growing number of autism spectrum disorder (ASD) candidate genes. Although encouraging, the volume and complexity of these data make it challenging for scientists, particularly non-geneticists, to comprehensively evaluate available evidence for individual genes. Described here is the Gene Scoring module within SFARI Gene 2.0 (https://gene.sfari.org/autdb/GS_Home.do), a platform developed to enable systematic community driven assessment of genetic evidence for individual genes with regard to ASD.

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Abrahams Brett S

Departments of Genetics and Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.

Arking Dan E

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Campbell Daniel B

Zilkha Neurogenetic Institute and Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Mefford Heather C

Department of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, WA, USA.

Morrow Eric M

Department of Molecular Biology, Cell Biology and Biochemistry; and Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.

Weiss Lauren A

IMHRO/Staglin Assistant Professor, Department of Psychiatry, Institute for Human Genetics, Center for Neurobiology and Psychiatry, UCSF, San Francisco, CA, USA.

Menashe Idan

MindSpec Inc., 8280 Greensboro Drive, Suite 150, McLean, VA, USA. | Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Wadkins Tim

MindSpec Inc., 8280 Greensboro Drive, Suite 150, McLean, VA, USA.

Banerjee-Basu Sharmila

MindSpec Inc., 8280 Greensboro Drive, Suite 150, McLean, VA, USA.

Packer Alan

Simons Foundation Autism Research Initiative, New York, NY, USA.

References (7)

7 references, click to expand

AutismKB: an evidence-based knowledgebase of autism genetics.
Nucleic Acids Res. 2012 Jan;40(Database issue):D1016-22 PMID: 22139918
A genome-wide linkage and association scan reveals novel loci for autism.
Nature. 2009 Oct 8;461(7265):802-8 PMID: 19812673
Functional impact of global rare copy number variation in autism spectrum disorders.
Nature. 2010 Jul 15;466(7304):368-72 PMID: 20531469
AutDB: a gene reference resource for autism research.
Nucleic Acids Res. 2009 Jan;37(Database issue):D832-6 PMID: 19015121
Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting.
Brain Res. 2011 Mar 22;1380:42-77 PMID: 21129364
Autism Genetic Database (AGD): a comprehensive database including autism susceptibility gene-CNVs integrated with known noncoding RNAs and fragile sites.
BMC Med Genet. 2009 Sep 24;10:102 PMID: 19778453
Advances in autism genetics: on the threshold of a new neurobiology.
Nat Rev Genet. 2008 May;9(5):341-55 PMID: 18414403

Article Info

Journal

Molecular autism

Abbr.

Mol Autism

ISSN

2040-2392

DOI

10.1186/2040-2392-4-36

Published

2013-10-03

Epub

2013-00-03

Pages

Language

English

Region

England

NLM ID

101534222

PMCID

PMC3851189

Grants

NIMH NIH HHS · R01 MH100027 · United States

External Links

PubMed source DOI: 10.1186/2040-2392-4-36 PMC Full Text View journal details

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SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs).

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