Cytotoxic T-cell response to respiratory syncytial virus in mice.

Journal of virology ·Vol. 56 ·No. 1 ·1985-10-00 ·Pages 55-9

Bangham CR, Cannon MJ, Karzon DT, Askonas BA

Abstract

The role of the humoral and cellular arms of the immune response in protection against respiratory syncytial virus (RSV) infection and in the pathogenesis of the severe forms of this disease is poorly understood. The recent demonstration that some inbred mouse strains can be infected with RSV has opened the way to a detailed investigation of RSV immunity. We report here the finding of major histocompatibility complex-restricted, RSV-specific memory cytotoxic T cells in the spleens of BALB/c and C57BL mice after intranasal infection; these T cells recognize the Long, A2, and 8/60 (human) strains of RSV. Both K and D locus major histocompatibility complex alleles can restrict the cytotoxic response; however, in the two haplotypes tested, Dd is a low-responder allele and Kb is a nonresponder allele for RSV. UV-inactivated RSV (when given intraperitoneally) can prime mice for development of cytotoxic T cell memory, restimulate cytotoxic T cell cultures in vitro, and form a target for the cytotoxic cells.

MeSH Terms

Animals Epitopes Genes, MHC Class II H-2 Antigens/immunology Immunologic Memory Major Histocompatibility Complex Mice Mice, Inbred Strains Respiratory Syncytial Viruses/immunology,radiation effects Spleen/immunology T-Lymphocytes, Cytotoxic/immunology Ultraviolet Rays

Chemicals

Epitopes H-2 Antigens

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bangham C R

Cannon M J

Karzon D T

Askonas B A

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25 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.56.1.55-59.1985

Published

1985-10-00

Pages

55-9

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC252469

Subset

External Links

PubMed source DOI: 10.1128/JVI.56.1.55-59.1985 PMC Full Text View journal details

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Cytotoxic T-cell response to respiratory syncytial virus in mice.

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