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PMID: 24183021 Published · ppublish English Historical Article Journal Article

AMPARs and synaptic plasticity: the last 25 years.

Neuron ·Vol. 80 ·No. 3 ·2013-10-30 ·Pages 704-17

Huganir RL, Nicoll RA

Abstract

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas of research in neuroscience. In the last 25 years we have come a long way in our understanding of the mechanisms underlying synaptic plasticity. In 1988, AMPA and NMDA receptors were not even molecularly identified and we only had a simple model of the minimal requirements for the induction of plasticity. It is now clear that the modulation of the AMPA receptor function and membrane trafficking is critical for many forms of synaptic plasticity and a large number of proteins have been identified that regulate this complex process. Here we review the progress over the last two and a half decades and discuss the future challenges in the field.

MeSH Terms
Animals History, 20th Century History, 21st Century Neuronal Plasticity/physiology Neurosciences/history Receptors, AMPA/metabolism Synapses/physiology
Chemicals
Receptors, AMPA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Huganir Richard L
Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: [email protected].
Nicoll Roger A
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
1097-4199
DOI
10.1016/j.neuron.2013.10.025
Email
[email protected]
Published
2013-10-30
Pages
704-17
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC4195488
Subset
IM
Grants
NIMH NIH HHS · R01 MH070957 · United States
External Links
PubMed source DOI: 10.1016/j.neuron.2013.10.025 PMC Full Text View journal details
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