A novel mutation that affects utilization of galactose in Saccharomyces cerevisiae.

Current genetics ·Vol. 2 ·No. 2 ·1980-10-00 ·Pages 115-20

Nogi Y, Fukasawa T

Abstract

A novel type of regulatory mutation for galactose metabolism in Saccharomyces cerevisiae is described. The mutation named gal11 was recessive, non-allelic to GAL4, GAL80, GAL2, or GAL3, and unlinked to the gene cluster of GAL1, GAL10, and GAL7. It caused a 'coordinate' reduction of galactokinase, galactose-1-P uridylyl transferase, and UDP-glucose 4-epimerase by a factor of more than 5, rendering the mutant cells galactose-nonfermenting. The effect of the mutation was manifested not only in cells grown on galactose but also in cells constitutively synthesizing the galactose-metabolizing enzymes.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Nogi Y

Research Unit for Molecular Genetics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

Fukasawa T

References (14)

14 references, click to expand

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Article Info

Journal

Current genetics

Abbr.

Curr Genet

ISSN

0172-8083

DOI

10.1007/BF00420623

Published

1980-10-00

Pages

115-20

Language

English

Region

United States

NLM ID

8004904

External Links

PubMed source DOI: 10.1007/BF00420623 View journal details

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A novel mutation that affects utilization of galactose in Saccharomyces cerevisiae.

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