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PMID: 2420768 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A monoclonal antibody against HLA-A11 and A24.

Human immunology ·Vol. 15 ·No. 3 ·1986-03-00 ·Pages 316-9

Foung SK, Taidi B, Ness D, Grumet FC

Abstract

A monoclonal IgG antibody was produced from a mouse immunized with an A11, A24; B27, B44 Epstein-Barr virus transformed B lymphoblastoid cell line. The antibody, A11.1M, by standard lymphocytotoxicity assay, reacts with all cells expressing HLA-A11 and -A24. Absorption studies with both A11+, A24- and A11-, A24+ platelets removed antibody reactivity against A11 and A24 lymphocytes. The shared antigenic determinant between A11 and A24, as defined by this antibody, A11.1M, represents a new "supertypic" determinant.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Blood Platelets/immunology Cross Reactions Cytotoxicity, Immunologic Epitopes/immunology HLA Antigens/immunology HLA-A Antigens HLA-A11 Antigen HLA-A24 Antigen Humans Immunoglobulin G/immunology Immunosorbent Techniques Lymphocytes/immunology Mice

Chemicals

Antibodies, Monoclonal Epitopes HLA Antigens HLA-A Antigens HLA-A11 Antigen HLA-A24 Antigen Immunoglobulin G

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Foung S K

Taidi B

Ness D

Grumet F C

Article Info

Journal

Human immunology

Abbr.

Hum Immunol

ISSN

0198-8859

DOI

10.1016/0198-8859(86)90006-6

Published

1986-03-00

Pages

316-9

Language

English

Region

United States

NLM ID

8010936

Subset

Grants

NIADDK NIH HHS · AM32075 · United States

NIADDK NIH HHS · AM33233 · United States

NHLBI NIH HHS · HL29572 · United States

External Links

PubMed source DOI: 10.1016/0198-8859(86)90006-6 View journal details

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A monoclonal antibody against HLA-A11 and A24.

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