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PMID: 2421164 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transfer of specificity by murine alpha and beta T-cell receptor genes.

Nature ·Vol. 320 ·No. 6059 ·1986-00-00 ·Pages 232-8

Dembić Z, Haas W, Weiss S, McCubrey J, Kiefer H, von Boehmer H, Steinmetz M

Abstract

T-cell receptor alpha- and beta-chain genes were isolated from a class I major histocompatibility complex-restricted cytotoxic T-cell clone and transferred by protoplast fusion into another cytolytic T-cell clone of different specificity. Expression of the transfected alpha and beta genes endowed the recipient cell with the specificity of the donor cell.

MeSH Terms

Alleles Animals Bacteriophage lambda/genetics Base Sequence Cell Line Clone Cells DNA, Recombinant Histocompatibility Antigens/immunology Hybridomas/immunology Mice Mice, Inbred C57BL Mice, Inbred DBA Nucleic Acid Hybridization RNA/genetics Receptors, Antigen, T-Cell/genetics,immunology T-Lymphocytes, Cytotoxic/immunology Transcription, Genetic Transfection

Chemicals

DNA, Recombinant Histocompatibility Antigens Receptors, Antigen, T-Cell RNA

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Dembić Z

Haas W

Weiss S

McCubrey J

Kiefer H

von Boehmer H

Steinmetz M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/320232a0

Published

1986-00-00

Pages

232-8

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

X03668, X03669, X03670, X03671, X03760, X03761, X03762

External Links

PubMed source DOI: 10.1038/320232a0 View journal details

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Transfer of specificity by murine alpha and beta T-cell receptor genes.

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