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PMID: 2422213 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Infection of monocyte/macrophages by human T lymphotropic virus type III.

The Journal of clinical investigation ·Vol. 77 ·No. 5 ·1986-05-00 ·Pages 1712-5

Ho DD, Rota TR, Hirsch MS

Abstract

Normal blood-derived monocyte/macrophages were found to be susceptible to infection in vitro by human T lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immunodeficiency syndrome. In addition, HTLV-III was recovered from monocyte/macrophages of patients infected with this virus. The above findings raise the possibility that HTLV-III-infected monocyte/macrophages may serve as a vehicle for the dissemination of virus to target organs and as a reservoir for viral persistence, as has been shown for other lentiviruses including visna virus and caprine arthritis encephalitis virus.

MeSH Terms
Acquired Immunodeficiency Syndrome/microbiology Cells, Cultured Deltaretrovirus/growth & development,isolation & purification Humans Macrophages/microbiology Male Monocytes/microbiology RNA-Directed DNA Polymerase/analysis Virus Replication
Chemicals
RNA-Directed DNA Polymerase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ho D D
Rota T R
Hirsch M S
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24 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI112491
Published
1986-05-00
Pages
1712-5
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC424579
Subset
IM
Grants
NCI NIH HHS · CA35020 · United States
External Links
PubMed source DOI: 10.1172/JCI112491 PMC Full Text View journal details
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