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PMID: 2423325 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Location of 'continuous' antigenic determinants in the protruding regions of proteins.

The EMBO journal ·Vol. 5 ·No. 2 ·1986-02-00 ·Pages 409-13

Thornton JM, Edwards MS, Taylor WR, Barlow DJ

Abstract

A simple method is described to locate 'antigenic' peptides from the alpha-carbon co-ordinates of a protein, based on protrusion from the protein's globular surface. A good correlation is found between those parts of a protein which protrude and the experimentally determined antigenic peptides in myoglobin, lysozyme and myohemerythrin. A comparison is made between the use of protrusion index, mobility, solvent accessibility and hydrophilicity for predicting the most likely antigenic peptides.

MeSH Terms
Epitopes/analysis Hemerythrin/analogs & derivatives,immunology Models, Molecular Muramidase/immunology Myoglobin/immunology Pigments, Biological/immunology Protein Conformation Proteins/immunology Surface Properties
Chemicals
Epitopes Hemerythrin Myoglobin Pigments, Biological Proteins myohemerythrin Muramidase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Thornton J M
Edwards M S
Taylor W R
Barlow D J
References (19)
19 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1986-02-00
Pages
409-13
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1166746
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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