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PMID: 2424596 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Depression of protective mechanism during the early phase of a viral infection in tumor-bearing mice and prevention by PSK.

Cancer immunology, immunotherapy : CII ·Vol. 22 ·No. 2 ·1986-00-00 ·Pages 114-8

Tsuru S, Nomoto K, Taniguchi M, Fujisawa H, Zinnaka Y

Abstract

Effector mechanisms responsible for resistance against ectromelia virus including antiviral activity of non-immune macrophages, antiviral antibody, delayed footpad reaction to viral antigen, and interferon induction after viral infection were depressed in BALB/c mice bearing syngeneic Meth A tumor. The degree of viral growth correlated well with the depression of delayed footpad reaction, antibody production, and interferon induction. Therefore, modification of macrophage functions by a tumor-bearing state and treatment with PSK may contribute to this modification of antiviral resistance, at an early phase of infection. Cytotoxic activity may not be the principal effector, since the cytotoxicity was induced in normal and tumor-bearing mice to almost the same extent yet an extensive viral growth occurred only in the latter.

MeSH Terms

Animals Antibodies, Viral/biosynthesis Antiviral Agents/therapeutic use Ectromelia virus/growth & development Ectromelia, Infectious/drug therapy,immunology Hypersensitivity, Delayed/immunology Immune Tolerance/drug effects Immunity, Innate/drug effects Interferons/analysis Kinetics Liver/analysis Male Mice Mice, Inbred BALB C Poxviridae Infections/immunology Proteoglycans/therapeutic use Spleen T-Lymphocytes, Cytotoxic/immunology

Chemicals

Antibodies, Viral Antiviral Agents Proteoglycans polysaccharide-K Interferons

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Tsuru S

Nomoto K

Taniguchi M

Fujisawa H

Zinnaka Y

References (22)

22 references, click to expand

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Article Info

Journal

Cancer immunology, immunotherapy : CII

Abbr.

Cancer Immunol Immunother

ISSN

0340-7004

DOI

10.1007/BF00199124

Published

1986-00-00

Pages

114-8

Language

English

Region

Germany

NLM ID

8605732

Subset

External Links

PubMed source DOI: 10.1007/BF00199124 View journal details

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Depression of protective mechanism during the early phase of a viral infection in tumor-bearing mice and prevention by PSK.

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