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PMID: 2426472 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein.

Journal of virology ·Vol. 59 ·No. 3 ·1986-09-00 ·Pages 755-8

Parsons SJ, McCarley DJ, Raymond VW, Parsons JT

Abstract

We investigated the location of binding sites of pp60src-specific monoclonal antibodies by immunoprecipitating a panel of structurally altered src proteins. Two families of antibodies which recognized epitopes mapping to either amino acid residues 28 to 38 or 92 to 128 were identified. The highly conserved nature of the epitope defined by residues 92 to 128 suggests that it may represent an important functional region of the cellular src protein.

MeSH Terms
Antibodies, Viral Avian Sarcoma Viruses/genetics,immunology Epitopes/analysis Mutation Oncogene Protein pp60(v-src) Oncogene Proteins, Viral/immunology Retroviridae Proteins/immunology
Chemicals
Antibodies, Viral Epitopes Oncogene Proteins, Viral Retroviridae Proteins Oncogene Protein pp60(v-src)
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Parsons S J
McCarley D J
Raymond V W
Parsons J T
References (25)
25 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.59.3.755-758.1986
Published
1986-09-00
Pages
755-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253256
Subset
IM
Grants
NCI NIH HHS · CA27578 · United States
NCI NIH HHS · CA29243 · United States
NCI NIH HHS · CA39438 · United States
External Links
PubMed source DOI: 10.1128/JVI.59.3.755-758.1986 PMC Full Text View journal details
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