Home LiteratureArticle Details
PMID: 24267881 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment

A new development in senescence.

Cell ·Vol. 155 ·No. 5 ·2013-11-21 ·Pages 977-8

Banito A, Lowe SW

Abstract

Cellular senescence is implicated in several pathological responses in the adult, with important repercussions in tumor suppression, wound healing, and aging. Two studies by Muñoz-Espín et al. and Storer et al. now reveal that senescence contributes to embryonic development, suggesting a primordial role in normal physiology.

MeSH Terms
Animals Cellular Senescence Embryonic Development Endolymphatic Sac/embryology Female Humans Male Mesonephros/embryology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Banito Ana
Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Lowe Scott W
References (10)
10 references, click to expand
  1. The quail mesonephros: a new model for renal senescence?
    J Vasc Res. 2006;43(6):581-6 PMID: 17028443
  2. Hallmarks of senescence in carcinogenesis and cancer therapy.
    Oncogene. 2004 Apr 12;23(16):2919-33 PMID: 15077154
  3. Senescence of activated stellate cells limits liver fibrosis.
    Cell. 2008 Aug 22;134(4):657-67 PMID: 18724938
  4. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing.
    Nat Cell Biol. 2010 Jul;12(7):676-85 PMID: 20526329
  5. Autophagy mediates the mitotic senescence transition.
    Genes Dev. 2009 Apr 1;23(7):798-803 PMID: 19279323
  6. Senescence is a developmental mechanism that contributes to embryonic growth and patterning.
    Cell. 2013 Nov 21;155(5):1119-30 PMID: 24238961
  7. Programmed cell senescence during mammalian embryonic development.
    Cell. 2013 Nov 21;155(5):1104-18 PMID: 24238962
  8. The essence of senescence.
    Genes Dev. 2010 Nov 15;24(22):2463-79 PMID: 21078816
  9. Programmed cell death in animal development and disease.
    Cell. 2011 Nov 11;147(4):742-58 PMID: 22078876
  10. Cancer and ageing: rival demons?
    Nat Rev Cancer. 2003 May;3(5):339-49 PMID: 12724732
Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2013.10.050
Published
2013-11-21
Pages
977-8
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC4702512
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NCI NIH HHS · P30 CA008748 · United States
NIA NIH HHS · AG16379 · United States
NIA NIH HHS · R01 AG016379 · United States
NCI NIH HHS · P01 CA013106 · United States
NIA NIH HHS · R56 AG016379 · United States
Corrections
CommentOn
PMID: 24238961
CommentOn
PMID: 24238962
External Links
PubMed source DOI: 10.1016/j.cell.2013.10.050 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2