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PMID: 2432042 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

What is a T-cell clone? Effect of rIFN on T-cell clone function and T-cell receptor gene rearrangement.

Human immunology ·Vol. 17 ·No. 3 ·1986-11-00 ·Pages 214-23

Chen LK, Mathieu-Mahul D, Sasportes M, Degos L, Bensussan A

Abstract

A T4+ proliferative, noncytotoxic cloned line acquires specific lytic function by treatment with recombinant interferon alpha or gamma. Simultaneous with the acquisition of this new cell function, a rearrangement of the T-cell receptor alpha gene occurs. These changes necessitate a revised concept of a T-cell clone regarding its T-cell receptor gene configuration and cell function.

MeSH Terms

Cell Line Clone Cells/physiology Collodion Cytotoxicity, Immunologic/drug effects Electrophoresis, Polyacrylamide Gel Epitopes/genetics Humans Interferon Inducers/pharmacology Interferons/pharmacology Male Receptors, Antigen, T-Cell/drug effects,genetics Recombinant Proteins/pharmacology T-Lymphocytes/drug effects,physiology,ultrastructure T-Lymphocytes, Helper-Inducer/drug effects,immunology

Chemicals

Epitopes Interferon Inducers Receptors, Antigen, T-Cell Recombinant Proteins Collodion Interferons

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Chen L K

Mathieu-Mahul D

Sasportes M

Degos L

Bensussan A

Article Info

Journal

Human immunology

Abbr.

Hum Immunol

ISSN

0198-8859

DOI

10.1016/0198-8859(86)90273-9

Published

1986-11-00

Pages

214-23

Language

English

Region

United States

NLM ID

8010936

Subset

External Links

PubMed source DOI: 10.1016/0198-8859(86)90273-9 View journal details

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What is a T-cell clone? Effect of rIFN on T-cell clone function and T-cell receptor gene rearrangement.

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