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PMID: 2432081 Published · ppublish English Journal Article

Reactivity of monoclonal antibodies to Rickettsia rickettsii with spotted fever and typhus group rickettsiae.

Journal of clinical microbiology ·Vol. 25 ·No. 1 ·1987-01-00 ·Pages 167-71

Anacker RL, Mann RE, Gonzales C

Abstract

Analysis of 15 spotted fever group (SFG) and 2 typhus group strains of rickettsiae with a panel of monoclonal antibodies revealed a number of shared and unique epitopes of the 120- and 155-kilodalton surface proteins. All of the SFG strains but neither of the typhus group strains reacted with antibody to the lipopolysaccharidelike antigen of Rickettsia rickettsii; possibly the lipopolysaccharidelike antigen is the common antigen which defines the SFG. North Carolina and Montana strains of R. rickettsii known to differ slightly in virulence for guinea pigs differed in at least one epitope of the 120-kilodalton protein.

MeSH Terms
Animals Antibodies, Bacterial/immunology Antibodies, Monoclonal/immunology Antigens, Bacterial/immunology Cross Reactions Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Epitopes/immunology Humans Immunologic Techniques Rickettsia/immunology Rickettsia prowazekii/immunology Rickettsia rickettsii/immunology
Chemicals
Antibodies, Bacterial Antibodies, Monoclonal Antigens, Bacterial Epitopes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Anacker R L
Mann R E
Gonzales C
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24 references, click to expand
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.25.1.167-171.1987
Published
1987-01-00
Pages
167-71
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC265851
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.25.1.167-171.1987 PMC Full Text View journal details
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