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PMID: 2432750 Published · ppublish English Journal Article

Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes.

Acta neuropathologica ·Vol. 71 ·No. 3-4 ·1986-00-00 ·Pages 216-23

Dickson DW, Yen SH, Suzuki KI, Davies P, Garcia JH, Hirano A

Abstract

Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these conditions the ballooned neurons contain phosphorylated epitopes recognized by monoclonal antibodies to neurofilaments, but not epitopes unique to Alzheimer neurofibrillary tangles and Pick bodies. The morphological features and immunohistochemical properties of ballooned neurons in these disorders bear resemblance to swollen neurons produced by neurotoxins that impair axoplasmic transport of neurofilaments. This finding, by analogy, suggests that impaired axoplasmic transport of neurofilaments may be a common mechanism in various dementing neurodegenerative diseases.

MeSH Terms
Aged Aged, 80 and over Alzheimer Disease/immunology Brain/immunology Brain Diseases/immunology Dementia/immunology Epitopes Humans Intermediate Filament Proteins/immunology Middle Aged Nerve Degeneration Neurofibrils/immunology
Chemicals
Epitopes Intermediate Filament Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Dickson D W
Yen S H
Suzuki K I
Davies P
Garcia J H
Hirano A
References (29)
29 references, click to expand
  1. The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique.
    Brain Res. 1976 Dec 3;117(3):423-35 PMID: 990939
  2. Corticodentatonigral degeneration with neuronal achromasia.
    Arch Neurol. 1968 Jan;18(1):20-33 PMID: 5634369
  3. Impaired slow axonal transport in wobbler mouse motor neuron disease.
    Ann Neurol. 1986 Jan;19(1):36-43 PMID: 3947038
  4. Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides.
    Am J Pathol. 1985 Aug;120(2):282-91 PMID: 2411142
  5. Ventral root axonopathy and its relation to the neurofibrillary degeneration of lower motor neurons in aluminum-induced encephalomyelopathy.
    Neuropathol Appl Neurobiol. 1985 Nov-Dec;11(6):407-30 PMID: 4094647
  6. Sharing of specific antigens by degenerating neurons in Pick's disease and Alzheimer's disease.
    N Engl J Med. 1985 Mar 14;312(11):700-5 PMID: 2579334
  7. Pathogenesis of experimental giant neurofilamentous axonopathies: a unified hypothesis based on chemical modification of neurofilaments.
    Brain Res. 1985 Sep;357(1):69-83 PMID: 2412663
  8. Two monoclonal antibodies recognize Alzheimer's neurofibrillary tangles, neurofilament, and microtubule-associated proteins.
    J Neurochem. 1987 Feb;48(2):455-62 PMID: 2432180
  9. The fine structure of the cervical spinal cord, ventral root and brachial nerves in the wobbler (wr) mouse.
    J Neuropathol Exp Neurol. 1975 Jan;34(1):12-27 PMID: 1117319
  10. The axon reaction: a review of the principal features of perikaryal responses to axon injury.
    Int Rev Neurobiol. 1971;14:49-124 PMID: 4948651
  11. Antibodies to heavy neurofilament subunit detect a subpopulation of damaged ganglion cells in retina.
    Nature. 1984 Jun 14-20;309(5969):624-6 PMID: 6203041
  12. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 38-1985. A 66-year-old man with progressive neurologic deterioration.
    N Engl J Med. 1985 Sep 19;313(12):739-48 PMID: 3897862
  13. Interactions between microtubules and neurofilaments in vitro.
    Ann N Y Acad Sci. 1985;455:509-24 PMID: 3909885
  14. An inherited disease similar to amyotrophic lateral sclerosis with a pattern of posterior column involvement. An intermediate form?
    Brain. 1959 Jun;82:203-20 PMID: 13849712
  15. Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central nervous system.
    N Engl J Med. 1985 Mar 14;312(11):714-9 PMID: 2579335
  16. Intermediate filament associated proteins.
    Ann N Y Acad Sci. 1985;455:32-56 PMID: 3909884
  17. One of the antigenic determinants of paired helical filaments is related to tau protein.
    J Biochem. 1986 May;99(5):1541-4 PMID: 2423512
  18. Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies.
    J Neurosci. 1986 Mar;6(3):650-60 PMID: 2420946
  19. Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.
    Proc Natl Acad Sci U S A. 1983 Oct;80(19):6126-30 PMID: 6577472
  20. Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy.
    Am J Pathol. 1985 Aug;120(2):292-303 PMID: 2411143
  21. Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis.
    J Neuropathol Exp Neurol. 1984 Sep;43(5):461-70 PMID: 6540799
  22. Aberrant neurofilament phosphorylation in Alzheimer disease.
    Proc Natl Acad Sci U S A. 1985 Jun;82(12):4274-6 PMID: 3159022
  23. Hallervorden-Spatz syndrome.
    Arch Neurol. 1974 Jan;30(1):70-83 PMID: 4808495
  24. The axon reaction in motor and sensory neurones of mice studied by a monoclonal antibody marker of neurofilament protein.
    J Neurol Sci. 1983 Aug;60(2):267-80 PMID: 6411867
  25. Intermediate filaments: possible functions as cytoskeletal connecting links between the nucleus and the cell surface.
    Ann N Y Acad Sci. 1985;455:1-17 PMID: 3909878
  26. Familial amyotrophic lateral sclerosis. A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells.
    Arch Neurol. 1967 Mar;16(3):232-43 PMID: 6018874
  27. Pick's disease. A clinical and ultrastructural study.
    Arch Neurol. 1972 Feb;26(2):97-108 PMID: 4332733
  28. Cortical degeneration with swollen chromatolytic neurons: its relationship to Pick's disease.
    J Neuropathol Exp Neurol. 1986 May;45(3):268-84 PMID: 3958759
  29. Neurofibrillary changes in human brain. An immunocytochemical study with a neurofilament antiserum.
    J Neuropathol Exp Neurol. 1983 Jan;42(1):69-79 PMID: 6337236
Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00688042
Published
1986-00-00
Pages
216-23
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00688042 View journal details
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