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PMID: 2433403 Published · ppublish English Journal Article

Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 49 ·No. 12 ·1986-12-00 ·Pages 1374-7

Jolkkonen J, Soininen H, Halonen T, Ylinen A, Laulumaa V, Laakso M, Riekkinen P

Abstract

Acetylcholinesterase, somatostatin-like immunoreactivity, and homovanillic acid levels were measured in the cerebrospinal fluid of 36 patients with early stages of Parkinson's disease and in 19 control patients. In patients with Parkinson's disease the levels of somatostatin-like immunoreactivity were lower than in the controls (p less than 0.01); these values were lowest in the demented Parkinsonian patients. Concentrations of homovanillic acid were also significantly lower in Parkinsonian patients (p less than 0.05). In contrast, no changes were observed in the acetylcholinesterase activity of patients with Parkinson's disease. The reduced somatostatin-like immunoreactivity in CSF agrees with previous post-mortem studies and indicates that Parkinson's disease and Alzheimer's disease may have some neurochemical features in common.

MeSH Terms
Acetylcholinesterase/cerebrospinal fluid Adult Aged Aged, 80 and over Dementia/cerebrospinal fluid,complications Female Homovanillic Acid/cerebrospinal fluid Humans Male Middle Aged Parkinson Disease/cerebrospinal fluid,complications Peptides/cerebrospinal fluid Substance P/cerebrospinal fluid
Chemicals
Peptides somatostatin-like peptides Substance P Acetylcholinesterase Homovanillic Acid
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Jolkkonen J
Soininen H
Halonen T
Ylinen A
Laulumaa V
Laakso M
Riekkinen P
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Article Info
Journal
Journal of neurology, neurosurgery, and psychiatry
Abbr.
J Neurol Neurosurg Psychiatry
ISSN
0022-3050
DOI
10.1136/jnnp.49.12.1374
Published
1986-12-00
Pages
1374-7
Language
English
Region
England
NLM ID
2985191R
PMCID
PMC1029121
Subset
IM
External Links
PubMed source DOI: 10.1136/jnnp.49.12.1374 PMC Full Text View journal details
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